[SPEAKER_00]: Hello and welcome to the Aquaman podcast.
[SPEAKER_00]: This is an exploration of woman kind.
[SPEAKER_00]: Here we discuss what it is to be a woman in the modern world while utilizing ancient and modern modalities in tandem to create a bounty of health for the body, mind and spirit.
[SPEAKER_00]: Good day everyone and welcome back to the pod.
[SPEAKER_00]: Before we get into talking all things Burberryen, let's pay our respects to the oldest past, present, and future residing on the lands of La Troida Tasmania, where I'm recording this podcast today.
[SPEAKER_00]: Always has, always will be baby.
[SPEAKER_00]: Before we get into this, I just want to tell you that Burberryen is not nature's exemplific and by the end of this, you will know a lot more about Burberryen than
[SPEAKER_00]: Most people who say that phrase, in fact, it acts a little bit more like metformin, which makes it perfect for PMOS, but it's also really great for a lot of different conditions and ailments and situations in the body as well.
[SPEAKER_00]: Before we get started, what is bervering?
[SPEAKER_00]: So bervering is not just a singular plant, it's an alkaloid that comes from roots, rhizomes, and even the stems of different plants, multiple
[SPEAKER_00]: In fact, for the key plant sources, we usually see our barberry, Chinese gold thread, golden seal and cork tree.
[SPEAKER_00]: It's color is right yellow, like bright bright yellow.
[SPEAKER_00]: And because it's so bright yellow, it actually used to be used as a die for clothing.
[SPEAKER_00]: This is actually what gives golden seal.
[SPEAKER_00]: It's signature name, golden seal is because it's golden in color.
[SPEAKER_00]: It has a long documented history, so it was used in Chinese medicine for over 2,000 years, primarily for gastrointestinal infections, diarrhea and fever, so you're probably already thinking, anti-microbial, and you're correct.
[SPEAKER_00]: It's also really prominent REUVATIC medicine, so it's really not a wellness trend at all.
[SPEAKER_00]: It's been used for
[SPEAKER_00]: thousands of years and in 2006 we saw lots of interesting research and that's when it kind of started to be picked up by the world-ness-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as-as
[SPEAKER_00]: In 2006, a study in metabolism by Kong at Al showed berbering lowered blood glucose comparably to metformin in type 2 diabetes.
[SPEAKER_00]: That's a really big deal.
[SPEAKER_00]: To find that a natural alcoholoid is as effective as a pharmaceutical drug metformin, which is so effective at lowering blood glucose, that's a really big deal and that was about 20 years ago now.
[SPEAKER_00]: So let's set the record straight on how it's not really natures ozempics, so berbering is not a GLP1.
[SPEAKER_00]: If you want to learn more about GOP ones and how GOP ones work in the body, what GOP ones are, how they are naturally occurring, which is why we have receptors fall them in the body, that I have a whole podcast on PMOS, previously called PCOS and GOP ones, where I talk about how it works.
[SPEAKER_00]: So you don't have to listen to the entire podcast, but you do just listen to that first bit where I talk about GOP ones and how they work.
[SPEAKER_00]: If you're more interested in that,
[SPEAKER_00]: But when we say that berberine is nature's ocempic, I think this comparison is really clinically lazy and whoever says this, I think it just shows how little they know about how berberine works in the body and what ocempic does and the differences between these two, they're both great, but not for the same reason.
[SPEAKER_00]: So just
[SPEAKER_00]: So, you know, if you don't want to go and listen to that other podcast, let's just read out what a semi-glutide is.
[SPEAKER_00]: So, is MPEG is a GLP1 receptor agonist.
[SPEAKER_00]: Structurally, it's 94% similar to the body's own GLP1 hormones.
[SPEAKER_00]: So, it binds directly to GLP1 receptors in the gut, pancreas, and hypothalamus, and it slows gastric emptying, so you feel full for longer.
[SPEAKER_00]: It stimulates insulin secretion, which decreases blood glucose because it's opening up more glucose channels in the cells of your body and your cells are actually using that glucose, which means it's really great for fatigue, if people are suffering from fatigue, suddenly your cells are really really good at uptaking that glucose.
[SPEAKER_00]: that really is dependent on insulin resistance, but is npx really good for that, or GLP ones I should say are really really good for that.
[SPEAKER_00]: It's suppresses glucogon and crucially it directly quiets hung as signals in the brain, which is why GLP one receptor agnes, like ozempic and Mondaro are really with the rate for addiction, so people have said that they don't feel lecturing you and they don't feel like smoking after this and that's because of its effects on the brain, which is just fantastic, amazing.
[SPEAKER_00]: It has a really, really long half life.
[SPEAKER_00]: So days versus the body's natural GLP-1, which lasts seconds to minutes, really.
[SPEAKER_00]: And if you're interested in the science, please go and listen to that other podcast where we talk about the needy gritty of that.
[SPEAKER_00]: It comes from a structural modification that can resist a DPP4 enzyme breakdown and allow a blooming binding in the blood, which allows a Zempic to work for longer, or GLP-1s to work for longer.
[SPEAKER_00]: Burberine does literally none of this.
[SPEAKER_00]: It does not work on GLP1 receptors, it does not work anything like OZMPIC all-manjaro.
[SPEAKER_00]: There is literally no similarity between GLP1 receptor agonists and burberine.
[SPEAKER_00]: It does not bind to GLP1 receptors, it does not slow gastric empty.
[SPEAKER_00]: It does not suppress appetite centrally in the hypothalamus, it is not even structurally similar to a GLP1.
[SPEAKER_00]: What is accurate though?
[SPEAKER_00]: Because there is some, I will say, some in italics similarities between these two things, but not many.
[SPEAKER_00]: It does improve blood glucose.
[SPEAKER_00]: It has modest weight effects, which I think is surprising to a lot of people.
[SPEAKER_00]: I think a lot of people will take burbring to lose weight.
[SPEAKER_00]: And when I say weight, I think a lot of people mean fat mass, but it has moderate modest effects on fat mass.
[SPEAKER_00]: But the mechanisms are entirely different and the compounds are not clinically interchangeable.
[SPEAKER_00]: So they work on different elements of your metabolism.
[SPEAKER_00]: And what I said before is that metformin is actually actually actually a far better comparison for berbreend than OZEMPIC because both berbreend and metformin activate AMPK, which is the cells energy master switch.
[SPEAKER_00]: Usually insulin attaches to the cell receptor site.
[SPEAKER_00]: And then that opens up a glucose channel and that lowers blood glucose.
[SPEAKER_00]: If you have insulin resistance, that pathway isn't working, so your other pathway to get glucose into the cell is through AMPK.
[SPEAKER_00]: And so that basically increases glucose transportation and it pushes glucose into the cell.
[SPEAKER_00]: You can usually activate this by exercise, which is pretty amazing, specifically weight training is really, really good at it, but any exercises good, but metformin and berbering also activate AMPK as well.
[SPEAKER_00]: This is a way that I comparison, and we're actually seeing more comparisons between burberry and metformant in the research than we see with those MPIC and GLP1.
[SPEAKER_00]: Let's move on to the research of burberry and what we actually know.
[SPEAKER_00]: So in 2008, Zang at Ellen the Journal of Clinical Indochronology and Metabolism, they found that burberry, which was supplemented at 500 milligrams three times a day,
[SPEAKER_00]: versus metformin at 500 milligrams three times a day of a 13 weeks, both produced approximately 20% reductions in HBA1C, which is a really great indicator of insulin resistance in the body, how insulin is working in the body and also overall looking at how your metabolism is working and whether it's functioning, whether it's not, and if we have high amounts of HBA1A1C,
[SPEAKER_00]: That's a no boino, if we see a reduction, that means overall our metabolic system is going to improve, and that has cardio metabolic protection as well.
[SPEAKER_00]: So that's pretty amazing.
[SPEAKER_00]: We're seeing that there is comparison between these two drugs.
[SPEAKER_00]: One of them in natural accolades, one a pharmaceutical drug, metformin.
[SPEAKER_00]: In 2012, Dong at Al, in a meta analysis of 14 randomized control trials,
[SPEAKER_00]: hypoglycemic drugs, including metformin, glyphoside, and rosycleanazone for blood glucose control.
[SPEAKER_00]: It consistently lowers fasting blood glucose, post-meal glucose, HPA1C across multiple RCTs.
[SPEAKER_00]: And so when we look at like an honest and reliable research, quality note, most of these studies are really short term.
[SPEAKER_00]: So, although this is really impressive, most of these studies can only get funding for about three to six months.
[SPEAKER_00]: So, and I will repeat this throughout and talk about the limitations of those studies because I think it's really important.
[SPEAKER_00]: Most of these studies, as I said before, are short-term moderate sample sizes.
[SPEAKER_00]: So, we don't have a huge amount of sample size, but you know, it doesn't necessarily mean it's a huge limitation in the research, but these are also predominantly in Chinese populations as well.
[SPEAKER_00]: So, we know it works for Chinese populations, because
[SPEAKER_00]: they've been done in those populations.
[SPEAKER_00]: We know they've been done for three to six months, but we don't actually have that much research on the comparability between metformin and burberine in longer periods of time.
[SPEAKER_00]: So that's just a limitation we have to take into account here.
[SPEAKER_00]: Next let's move on to lipids, also known as fats.
[SPEAKER_00]: So there is a meta-analysis, approximately 20 to 25 average reductions in triglycerides, which is really impressive.
[SPEAKER_00]: The mechanism here is PCSK9 inhibition.
[SPEAKER_00]: So Burverine will inhibit this enzyme.
[SPEAKER_00]: And this enzyme degrades LDL receptors on liver cells, which means that more LDL stays in the
[SPEAKER_00]: which is a kind of no-bueno.
[SPEAKER_00]: The whole conversation around cholesterol is a lot more nuanced and complicated than LDL bad hates the ill good, but generally seeing high triglycerides and high LDL isn't so great for your cardio metabolic health.
[SPEAKER_00]: So if we have less of this enzyme and more of that LDL cholesterol, that doesn't necessarily mean we're going to have a more healthy individual.
[SPEAKER_00]: What berbering does is that it stops this enzymes from breaking down those receptor sites.
[SPEAKER_00]: So LDL can attach to receptor sites and therefore we see less LDL in the blood system.
[SPEAKER_00]: This is good.
[SPEAKER_00]: So this means we consistently reduce LDL cholesterol and total cholesterol over studies.
[SPEAKER_00]: And the effect on HDL is inconsistent across studies.
[SPEAKER_00]: So we can't really over claim that we can't say it because berbering increases.
[SPEAKER_00]: LDL receptor sites in liver, therefore we're seeing less LDL, therefore we see more HGL.
[SPEAKER_00]: That's not necessarily the case.
[SPEAKER_00]: Again, cholesterol is complicated and nuanced.
[SPEAKER_00]: I'm going to do a podcast with an expert on cholesterol really soon because I think it's really misunderstood.
[SPEAKER_00]: And I think there's a lot of misinformation around cholesterol.
[SPEAKER_00]: I'm going to get into it here.
[SPEAKER_00]: But that's what we know about lipids and LDL, specifically, and berbering.
[SPEAKER_00]: Let's move on to cardiovascular and inflammation, so we're seeing a modest blood pressure reduction across several studies, and we're generally seeing that berbering has an anti-inflammatory effect on the body too, which is amazing.
[SPEAKER_00]: It reduces CRP into lukin 6,
[SPEAKER_00]: TNF alpha, which are key markers of systemic chronic inflammation for my PMOS girlies listening, you know that these are really, really high.
[SPEAKER_00]: A lot of women with PMOS have had seen their labs and they've had a IL-6 and they've also seen CRP, those are the most common ones off the charts, and Burberry can bring these down.
[SPEAKER_00]: There's also some emerging research on cardiac arrhythmiers, so complex territory, I have to say, again, very nuanced, very complicated and relevant to safety.
[SPEAKER_00]: So we'll cover that in section six, so these two things will connect.
[SPEAKER_00]: Next let's move on to weight and body composition.
[SPEAKER_00]: This is the one that everyone's really really interested in.
[SPEAKER_00]: And I think, of course, it's important because we're generally seeing a more overweight and obese population in Western countries, especially for females, and that doesn't necessarily mean overarchingly good health outcomes over the long-term period, and berbering does have some good effects in this space, but I will say again, it is probably
[SPEAKER_00]: impressive part of the research.
[SPEAKER_00]: But everyone is listening to Burberry and because they want to know about this aspect, so let's get into it.
[SPEAKER_00]: The average weight loss versus placebo across meta-analysis is approximately two to three kilos.
[SPEAKER_00]: So generally when we look at meta-analysis, we're seeing that those who take Burberry and versus a placebo lose two to three extra kilos, and then people who didn't, which is pretty cool.
[SPEAKER_00]: But I have to say, Burberry is not a weight loss drug.
[SPEAKER_00]: It does not suppress
[SPEAKER_00]: and weight affects the downstream consequences of improved metabolic regulations.
[SPEAKER_00]: So, burbring is really, really great at resetting our metabolism and cardiovascular system, and our gut, and our brain.
[SPEAKER_00]: All of these other systems in the body and the downstream positive impact is weight loss, which is amazing.
[SPEAKER_00]: But in of itself, we can't really think about burbring as just equaling weight loss, because it takes a lot more time.
[SPEAKER_00]: It's effect on weights is also
[SPEAKER_00]: So let's talk about why the effect is modest, so adaptive thermogenesis and the set point.
[SPEAKER_00]: So when caloric intakes drops or metabolic efficiency improves the body adapts.
[SPEAKER_00]: Metabolism adjusts slightly, appetite hormones shift to increase hunger and energy storage becomes more efficient.
[SPEAKER_00]: So what is this?
[SPEAKER_00]: This is called adaptive thermogenesis.
[SPEAKER_00]: I will be talking about weight loss in the future.
[SPEAKER_00]: I'm just figuring out how I want to talk about it because we're living through
[SPEAKER_00]: a skinny talk, we're living through also a period of time where we're seeing overweight obesity increasing as well.
[SPEAKER_00]: And I want to talk about it in a conscious kind way.
[SPEAKER_00]: So I'm just figuring out that space.
[SPEAKER_00]: So if you're interested in body recomposition and maybe losing weight in a healthy way, that content is coming.
[SPEAKER_00]: I am just feeling it out just so you know.
[SPEAKER_00]: But let's talk about adaptive thermogenesis.
[SPEAKER_00]: So say you're eating 2000 calories a day and you're exercising three days a week and you go, you know what, I want to lose two to three kilos.
[SPEAKER_00]: Cool.
[SPEAKER_00]: So you decrease your intake to 1,800 calories and you start working out four to five days a week.
[SPEAKER_00]: You would think in that period of time you're going to lose weight and you would be correct.
[SPEAKER_00]: Okay, so.
[SPEAKER_00]: NG cannot be created nor destroyed, calories and calories out, does work to a certain degree.
[SPEAKER_00]: But the body takes note.
[SPEAKER_00]: And as a woman, if you're my size, for example, I'm 165 centimeters tall.
[SPEAKER_00]: I don't know how much that is in feet and inches.
[SPEAKER_00]: I'm sorry for my North American girlies.
[SPEAKER_00]: If I started to eat 1,800 calories a day,
[SPEAKER_00]: What would happen is that my body would go, we're in taking less food.
[SPEAKER_00]: So we're kind of gonna go into a bit of starvation mode here.
[SPEAKER_00]: We are going to become really efficient at storing fat when there's a slight excess and we're actually going to slow down metabolism.
[SPEAKER_00]: So we're going to burn energy less.
[SPEAKER_00]: So this is why people who lose a huge amount of weight in a short period of time, like on the biggest loser, gain it back.
[SPEAKER_00]: it's because their body has learnt to run at a really, really, really local or restriction.
[SPEAKER_00]: And when you go back to eating kind of a normal diet or you start increasing your calories and your intake after losing your weight, then you can gain that weight back.
[SPEAKER_00]: I think there are some statistics out there that suggest that.
[SPEAKER_00]: I think it's like 70 to 95% of people will regain all of the weight back and might even gain some more back.
[SPEAKER_00]: It's because they haven't reversed dieted.
[SPEAKER_00]: So when you lose weight, you need to kind of
[SPEAKER_00]: kind of if you're watching this on YouTube, you decrease your caloric restriction really really low, you get down to the lowest point and then you slowly increase it.
[SPEAKER_00]: You just can't go back to what you were eating before because the adaptive thermogenesis is going to govern that and you're probably going to gain that weight back.
[SPEAKER_00]: especially if you're eating a really, really low amount of calories in that period of time where you are trying to lose weight and you are dieting.
[SPEAKER_00]: So this is basically your body's set point difference.
[SPEAKER_00]: So it's not a failure.
[SPEAKER_00]: It's not a lack of willpower.
[SPEAKER_00]: It's your biology, maintaining equilibrium.
[SPEAKER_00]: And where this comes from is from human starving.
[SPEAKER_00]: it makes perfect sense.
[SPEAKER_00]: This is a part of our starvation mode that helps humans survive and pass on their genes.
[SPEAKER_00]: Okay, so your body is always going to prioritize surviving and it's going to lock in starvation and go, oh, okay, we're in an environment where that can happen so it can happen again.
[SPEAKER_00]: So it's going to protect you from it.
[SPEAKER_00]: it's kind of a loving, loving defense mechanism that your body has in place.
[SPEAKER_00]: Burberryen works well within this adaptive thermogenesis system, not around it or against it, so it won't trump adaptive thermogenesis.
[SPEAKER_00]: It can work with it.
[SPEAKER_00]: And so again, let's bring in that key distinction between Burberryen, which works more like metformin and GOP1, semi-glugetides, like Ozenpican Monjaro.
[SPEAKER_00]: So GOP1's agonist override appetite signaling centrally.
[SPEAKER_00]: So you just don't feel hungry and therefore you don't eat.
[SPEAKER_00]: And when you do eat, it slows down gastric emptying, so you feel very, very full on a smaller amount of food.
[SPEAKER_00]: And they directly quiet hunger cues in the hypothalamus.
[SPEAKER_00]: Burbering does not do this, and this is why weight not lost magnitude from Burbering is really, really, really modest in comparison to your GLP one medications, which I would say really hard core.
[SPEAKER_00]: GLP one medications are really, really hard core.
[SPEAKER_00]: They are being oversubscribed.
[SPEAKER_00]: I'm not gonna go into that whole tangent, but this is why comparing Burbering again to a GLP one,
[SPEAKER_00]: is really clinically misleading.
[SPEAKER_00]: It just shows that you haven't really read the research, you don't actually understand the nuances between these two things.
[SPEAKER_00]: Going on from that body composition improvements with burbering, so reduced waste to conference and visceral fat, which are really clinically meaningful outcomes.
[SPEAKER_00]: I think we need to move away from BMI, I think most people have.
[SPEAKER_00]: and kind of look closer at Dexer and waste circumference, specifically waste circumference and visceral fat, because since visceral fat is more metabolically active and it also drives systemic inflammation.
[SPEAKER_00]: So if you're taking burber and you've noticed, a decrease in visceral fat and your waste circumference, that's a really great thing.
[SPEAKER_00]: We think as fat as just inert, but it's not.
[SPEAKER_00]: It's not inert if there's too much of it, and if there's too much of a certain amount of different fat at a post tissue, then that can improve or decrease your chances.
[SPEAKER_00]: or inflammation the body.
[SPEAKER_00]: So we'll talk about different fats later in this podcast.
[SPEAKER_00]: So you understand how burbering works on each of them, which is really, really fascinating.
[SPEAKER_00]: So how does burbering work?
[SPEAKER_00]: Let's talk about AMPK.
[SPEAKER_00]: I love AMPK.
[SPEAKER_00]: We just spoke about it shortly before, but let's get into it.
[SPEAKER_00]: So AMPK is AMP activated protein kinase.
[SPEAKER_00]: And this is the cell's primary energy sensor and metabolic regulator.
[SPEAKER_00]: So what does AMP do AMPK do when it is activated?
[SPEAKER_00]: When AMPK senses low cellular energy, so low ATP to AMP ratio, it increases glucose uptake into cells, it stimulates fatty acid oxidation.
[SPEAKER_00]: Stimulation of fatty acid oxidation is basically a fancy way of using stored fat, turning it into ATP and using it as an energy source.
[SPEAKER_00]: So we're using fat as an energy source when we see AMPK being turned on.
[SPEAKER_00]: It also shuts down energy-expensive biosynthetic processes, like statsynthesis and cholesterol production.
[SPEAKER_00]: So how burying activates a NPK, it mildly inhibits complex one of the mitochondrial electron transport chain.
[SPEAKER_00]: If you studied nutrition or dietetics, woo, baby.
[SPEAKER_00]: the electron transport chain, stralled into my brain.
[SPEAKER_00]: I have PTSD from learning that anyway.
[SPEAKER_00]: Slightly reduces ATP production and the cell takes low energy and AMP case, which is on to restore balance.
[SPEAKER_00]: Again, the best way to do this is exercise, and Burberryen is also really good at this, and so is metform.
[SPEAKER_00]: Metformin also activates AMPK via my mitochondrial complex one inhibition, which is why clinical comparisons between Burberryen and Metformin is clinically valid.
[SPEAKER_00]: and unlike OZEM pick comparisons, okay?
[SPEAKER_00]: And that's the last thing I'm going to say about OZEM pick for the rest of the podcast I promise.
[SPEAKER_00]: Bebering also works on insulin signaling, which is body fantastic for my PMOS girls.
[SPEAKER_00]: So it up regulates glut4.
[SPEAKER_00]: Glut4 is basically this cellular process where we are taking up these transporters to the cell membrane.
[SPEAKER_00]: capturing glucose, bringing it into the cell, taking it to the mitochondria so we can use glucose as an energy source.
[SPEAKER_00]: The impressive thing about berbering in this case is that it can improve glucose update even in cells that are insulin resistant.
[SPEAKER_00]: It activates downstream parts of glucose uptake pathways that bypass the step broken by insulin resistance.
[SPEAKER_00]: So
[SPEAKER_00]: Again, remember insulin resistance, it does use Glat4 to get glucose into the cell, but it's a different intercellular process.
[SPEAKER_00]: So insulin attaches to a receptor site, and there is a cell process that turns on Glat4 and gets Glat4 to go up to the cell membrane and capture glucose and bring it into the cell.
[SPEAKER_00]: If you have insulin resistance, the receptor is going to be resistant to capturing, listening to, and even responding to insulin, therefore insulin resistance.
[SPEAKER_00]: AMPK is the backdoor way, okay?
[SPEAKER_00]: It's almost like insulin resistance is the way that glucose gets into the club i.e.
[SPEAKER_00]: the cell through the bounce-out.
[SPEAKER_00]: The bounce-out is the receptor and the rest is just like, oh no, we're full.
[SPEAKER_00]: We don't want any more glucose in here.
[SPEAKER_00]: Even though the cell is starving and she's like, hey, we need glucose.
[SPEAKER_00]: So it's almost like when you move or when you take burberine, it's like exercise if you could personify exercise, metformin or burberin.
[SPEAKER_00]: It's people who kind of cut into the line and say, hey, there's a backdoor, let's get into the backdoor.
[SPEAKER_00]: Right?
[SPEAKER_00]: And so that's AMPK turning on clock 4, capturing the glucose, bringing it into the cell.
[SPEAKER_00]: You get it?
[SPEAKER_00]: You get it.
[SPEAKER_00]: And so that's why when people say burberine can improve glucose uptake even in cells that are insulin resistant, it's because it's taking the back door way.
[SPEAKER_00]: It's taking AMPK instead of insulin.
[SPEAKER_00]: Okay?
[SPEAKER_00]: There's also the IRS 1, P13K and AKT pathway.
[SPEAKER_00]: So burberine activates key downstream signaling steps in the insulin cascade, making cells
[SPEAKER_00]: So insulin can also work on the cell and make the bouncer listen to the insulin at the cell receptor site by way of making that intracellivial process that turns on glut4 more sensitive, which is huge.
[SPEAKER_00]: That's a really, really positive impact that Burberry has, especially for people who have insulin resistance.
[SPEAKER_00]: It also reduces hepatic glucose output.
[SPEAKER_00]: So it suppresses gluconeogenesis, making you glucose and glyconeogenesis, which is releasing stored glucose in the liver.
[SPEAKER_00]: You'll liver.
[SPEAKER_00]: I don't think a lot of people understand.
[SPEAKER_00]: You'll liver is one of the most important blood glucose regulating machines we have in the body.
[SPEAKER_00]: And it does this via gluconeogenesis and glyconeogenesis.
[SPEAKER_00]: And so that's basically dumbing glucose into the blood system.
[SPEAKER_00]: When we see blood glucose in the blood system, we see more insulin.
[SPEAKER_00]: So when verbering comes along, it reduces hepatic glucose output.
[SPEAKER_00]: And this directly reduces fasting glucose.
[SPEAKER_00]: Since the liver is now, is now not a major source of glucose.
[SPEAKER_00]: in the blood system.
[SPEAKER_00]: Bibery also works on DPP4 inhibition.
[SPEAKER_00]: So you heard of DPP4 at the start of this podcast.
[SPEAKER_00]: And so that is an enzyme that breaks down GLP1s.
[SPEAKER_00]: So that's kind of how OZempeek, Majora, and these modern GLP1 receptor agonist work is that they are really resistant to being broken down by enzymes, which means they can stay in the body for days to weeks, versus seconds to minutes, which is how are naturally occurring GLP1s work.
[SPEAKER_00]: mildly, moderately.
[SPEAKER_00]: So it's not a huge effect, but it does do this in Hibbert's DPP4, and this might slightly prolong the activity of the body's own naturally produced GLP ones after meals, which is what might explain when people take burberry, they just start to notice their less hungry.
[SPEAKER_00]: I think there's a few different reasons behind this.
[SPEAKER_00]: One, it's allowing your body to mobilize fat storage as energy, as we spoke about before.
[SPEAKER_00]: So that's one way, it's because your body is like, we don't actually need you to intake that much more food because we have food here that we're using because burbering increases that.
[SPEAKER_00]: But it also could be because it decreases GLP ones naturally occurring in your body from breaking down.
[SPEAKER_00]: Is this an argument for someone listening who is taking ozampic or monjaro to take berbering?
[SPEAKER_00]: Absolutely not.
[SPEAKER_00]: You need to talk to your doctor about that.
[SPEAKER_00]: I mean, theoretically it might work, but I'm not advising on that at all, please.
[SPEAKER_00]: I'm going to be very, very clear on that.
[SPEAKER_00]: But I think that's just one way we could think about it.
[SPEAKER_00]: That's like the one similarity.
[SPEAKER_00]: There's one singular similarity really that we see between these two compounds.
[SPEAKER_00]: You might be thinking, wow, Burberry is really really incredible.
[SPEAKER_00]: It must be absorbed quite readily into our blood circulation, incorrect, so Burberry's oral bioavailability into systemic circulation is only three to five percent.
[SPEAKER_00]: Okay, so how can I have all of these amazing systemic impacts on the body if there's only a small amount, orally getting into the blood circulation?
[SPEAKER_00]: I say that low systemic absorption might actually be the point here.
[SPEAKER_00]: So high concentrations in the gut lumen, the mean burberry and acts directly on gut bacteria,
[SPEAKER_00]: It stimulates gut hormone secretion, including GLP ones from intestinal L cells, and modulates intestinal glucose absorption before it never needs to reach the bloodstream.
[SPEAKER_00]: Burberry might be more effective in the body because it acts on the gut instead of our systemic circulation.
[SPEAKER_00]: Therefore, all of Burberry's metabolic effects are actually downstream from what it's doing in the gut, which is really important.
[SPEAKER_00]: So let's talk about the gut later on in this episode.
[SPEAKER_00]: First, let's just talk about adipose tissue because we're kind of still
[SPEAKER_00]: In that realm, I want to talk about Fat tissue out of post tissue in the different types and how burberryen can act on different Fat tissue, because I think this is really fascinating.
[SPEAKER_00]: Again, Fat tissue is not in the note, part of your body.
[SPEAKER_00]: It kind of acts as an endocrine organ and it is an organ in itself.
[SPEAKER_00]: Out of post tissue is a living endocrine organ that's a creates hormones, immune messengers, metabolic regulators, and when the system is too speculated, it drives insulin resistance and it increases systemic inflammation.
[SPEAKER_00]: in metabolic dysfunction.
[SPEAKER_00]: So why that?
[SPEAKER_00]: Not so great.
[SPEAKER_00]: We don't want to see a huge amount of white fat on an individual body.
[SPEAKER_00]: Brown fat burns energy to create heat through thermogenesis and it's metabolically really protective.
[SPEAKER_00]: So the more brown fat we see, the higher likelihood that this individual is going to be metabolically,
[SPEAKER_00]: and cardiovascular a lot healthier.
[SPEAKER_00]: Bage fat is what sells that begin to behave like brown fat, and they can be induced by exercise, cold exposure, and metabolic interventions, including AMPK activation.
[SPEAKER_00]: Beberine increases something called any poedectin.
[SPEAKER_00]: It's really interesting.
[SPEAKER_00]: I'm always reading these terms, and then I have to read it aloud, and I've never heard anyone say these words before.
[SPEAKER_00]: So bear with me.
[SPEAKER_00]: So Anabodectin is a hormone secreted by fat cells that improve insulin sensitivity and reduces inflammation and it's consistently low in metabolic syndrome and PMOS, Burberine increases it, which is amazing.
[SPEAKER_00]: Burberine also reduces resistance.
[SPEAKER_00]: So resistance is a pro-inflammatory adipocine that promotes insulin resistance and Burberine also reduces this, which is good.
[SPEAKER_00]: Burbering also promotes fat browning via AMPK activation, Burbering promotes beige and brown fact actively.
[SPEAKER_00]: It increases thermogenic capacities, so it kind of turns this inert white fat that's highly associated with inflammation into something that's more biologically active and starts to activate at via AMPK signaling.
[SPEAKER_00]: This is the most likely contributor to the modest body composition improvements seen in trials, independent of glucose regulation.
[SPEAKER_00]: The last part of Burberry and its connection to our cardio metabolic system and our hunger system is its impacts on leptin.
[SPEAKER_00]: So leptin, if you didn't know, is a hormone that is released from our stomach when we are full.
[SPEAKER_00]: So it signals to us that we are full and we don't want to eat anymore.
[SPEAKER_00]: But when we see metabolic dysfunction, we generally see the brain stops hearing the leptin signal, even when fat stores are sufficient.
[SPEAKER_00]: Lipton is produced by fat cells to tell the brain that energy reserves are adequate, it's also released from a stomach when we are full.
[SPEAKER_00]: And in Lipton resistance, this communication breaks down, fullness signals are missed and appetite remains elevated.
[SPEAKER_00]: So you can sit down, have a full meal, and you still feel hungry.
[SPEAKER_00]: So berbering impacts, left in a lot.
[SPEAKER_00]: So there's a lot of evidence that shows improving Lipton sensitivity.
[SPEAKER_00]: likely via a MPK activation and reduction of hypotherlamic inflammation restoring the brain's ability to receive satiety signals.
[SPEAKER_00]: So again, does Burberryen make us feel fuller?
[SPEAKER_00]: Yes, it does.
[SPEAKER_00]: By way of lifting, but it doesn't in the same way that is MPK or Monjaro or any other GLP one does, but it's really distinct from just straightforward appetite suppression.
[SPEAKER_00]: GLP ones will shut down your body's ability to feel hungry, whereas Burberryen sensitizes your brain to lips and again, buy AMPK and decreasing inflammation in the brain.
[SPEAKER_00]: Let's talk about Burberryen and the gut.
[SPEAKER_00]: This is the most interesting part of Burberryen, I would say.
[SPEAKER_00]: Everyone's obsessed with Burberryen and weight loss, and of course, everything we've just learned about is fantastic.
[SPEAKER_00]: But Burberryen's impact on the gut, that's where most of its impacts are.
[SPEAKER_00]: Let's talk about it.
[SPEAKER_00]: In a landmark 2015 study by Zoo at L in Nature Communications,
[SPEAKER_00]: Germ-free mice, those who had no gut bacteria, showed significantly reduced metabolic effects from burberry and compared to mice with intact microbiomes.
[SPEAKER_00]: This is a compelling evidence that the microbiome mediates of substantial portion of burberry insactions.
[SPEAKER_00]: So the translation of this is burberry in plus a healthy diverse gut bacteria equals synergy.
[SPEAKER_00]: Burberry in a depleted or disfired gut equals diminished metabolic returns.
[SPEAKER_00]: So you need somewhat of a healthy gut
[SPEAKER_00]: So what does burpering actually do to gut bacteria?
[SPEAKER_00]: So it increases acomansia, which is a species that lives in the gut, mucous layup, and it supports gut barrier integrity, reduces intestinal hyperpermubility, so reduces the risk of leaky gut, and it is associated with metabolic health.
[SPEAKER_00]: So it's constantly depleted in metabolic syndrome obesity and type 2 diabetes.
[SPEAKER_00]: And we're also seeing women with PMOS tend to also have lower diversity of this specific microbe in their gut
[SPEAKER_00]: Beverein also increases short chain fatty acid producing bacteria.
[SPEAKER_00]: So short chain fatty acids budurate, acetate, propyleneate.
[SPEAKER_00]: There's so many different positive ones, but those are the three that really stand out in the research with PCOS.
[SPEAKER_00]: Those are the ones that really stand out in research with Beverein.
[SPEAKER_00]: The gut's bacteria most important output for human health is short chain fatty acids.
[SPEAKER_00]: Let's talk about buterate.
[SPEAKER_00]: So primary fuel for colonocytes.
[SPEAKER_00]: So your colonocytes are your colon lining cells.
[SPEAKER_00]: They need buterate in order to function.
[SPEAKER_00]: It's like their ATP.
[SPEAKER_00]: It strengthens tight junctions between cells so that reduces leaky gut.
[SPEAKER_00]: It regulates me causal immune function and it enters circulation to have anti-inflammatory effects.
[SPEAKER_00]: So buterate pretty amazing little molecule.
[SPEAKER_00]: ProprietNA travels to the liver and modulates gluconeogenesis, which is directly relevant to fasting blood glucose and blood glucose regulation via the liver and acetate systemic energy substrate, and it's also involved in appetite regulation via the hypothalamus.
[SPEAKER_00]: Beberine is also really great at modulating bile acid metabolizing bacteria, so beberine affects the bile acid pool via these bacteria, which then signals through FXR and TGR-5 receptors,
[SPEAKER_00]: Regulate downstream glucose metabolism and lipid handling.
[SPEAKER_00]: Microbial activity as well.
[SPEAKER_00]: So it's active against H.P.
[SPEAKER_00]: Laura.
[SPEAKER_00]: So H.P.
[SPEAKER_00]: Laura is bacteria that drills into your small intestine and your stomach, and it takes a lot of iron, not so great.
[SPEAKER_00]: Hathenogenic E-coli strains and staff infections.
[SPEAKER_00]: And this is a broad anti-microbial action, which is why cycling really matters.
[SPEAKER_00]: So you can't just take burbrine indefinitely.
[SPEAKER_00]: you have to cycle on and off because it is an antimicrobial, even though it's gray and it works again against H.P.
[SPEAKER_00]: Lorei, staff, and it can work against candidates.
[SPEAKER_00]: Well, you can't just stay on it all the time because it will decrease your diversity.
[SPEAKER_00]: But first let's talk about the short-chain fatty acid cascade and why this matters systematically.
[SPEAKER_00]: Burberry increases short-chain fatty acid producing bacteria, which means we have more short-chain fatty acids.
[SPEAKER_00]: which means we have a stronger gap area, we have reduced systemic inflammation, we have improved herpatic glucose regulation and we have better metabolic signaling in the brain.
[SPEAKER_00]: This cascade is why Berberine's metabolic effects are more broad than its direct molecular mechanisms would suggest.
[SPEAKER_00]: The microbiome is really doing the biggest portion of work.
[SPEAKER_00]: on the rest of the body.
[SPEAKER_00]: It's berbering working on the gut and all of the effects on the gut, on the rest of the body.
[SPEAKER_00]: What did a buckety say years and years ago?
[SPEAKER_00]: The health resides in the gut and berbering works on the gut and that's why it's so effective.
[SPEAKER_00]: As I said before, we have to cycle on and off of berbering because there is a risk of it decreasing microbial diversity and it's also not recommended to take berbering alongside probiotics because it is an antimicrobial.
[SPEAKER_00]: It's almost like taking an antibiotic alongside your probiotic, so if you are wanting to increase your diversity and take burbering at the same time, it's really important to probably take burbering away from your fermented foods and from your probiotics.
[SPEAKER_00]: So if you're having sour crowd with your lunch, you might not want to have burbering with your lunch.
[SPEAKER_00]: If you're having it with your probiotic in the morning, that might not be good, but of course clinical guidance
[SPEAKER_00]: not all microbes are the same, not all microbes are going to be negatively impacted by burbrane.
[SPEAKER_00]: So this is something that you need to talk to your practitioner about.
[SPEAKER_00]: And also alongside this, most of the research we have on burbrane and its effects on the gut are three months long in human beings.
[SPEAKER_00]: Again, because studies are really expensive to run.
[SPEAKER_00]: So there's lots of limitations and what we can say.
[SPEAKER_00]: We don't know what the long term impacts on burbrane on the human gut are.
[SPEAKER_00]: We can assume from the limited research we have from three
[SPEAKER_00]: but we don't know really.
[SPEAKER_00]: We don't have that research so we can't be certain.
[SPEAKER_00]: Let's talk about Burberry and Candida.
[SPEAKER_00]: I have a square or like a carousel on most of my social media that went kind of viral with Burberry and Candida because Burberry and
[SPEAKER_00]: is Candida's final boss.
[SPEAKER_00]: I will say that it's probably one of the most important things that you could be taking or integrating if you have frequent Candida problems in your body.
[SPEAKER_00]: Candida is a commensal yeast, kept in checked by a healthy gut microbiome and immune function.
[SPEAKER_00]: When your balance shifts, so if you take an antibody audit, if you have high estrogen, if you have poor blood sugar control or microbiome disruption, Candida can overgrow its opportunistic.
[SPEAKER_00]: at best.
[SPEAKER_00]: By glucose also feeds Candida, so insulin resistance and elevated blood glucose create a richer glucose environment in the gut, which is why women with PMOS and generally blood glucose problems and blood regulation problems tend to have Candida problems, so they might have lots of yeast on their scalp, they might have lots of white on their tongue, they might have frequent yeast infections, they might be really sensitive to yeast foods, they might get bloated
[SPEAKER_00]: Brain fog, I mean, Candida's impacts on the body are quite synergistic because it is everywhere in the body.
[SPEAKER_00]: I'm sure it has some benefit, which is why it's there, but it might not, but this is why Burberry is really good at it.
[SPEAKER_00]: So Burberry directly acts on Candida.
[SPEAKER_00]: It disrupts its biofilm.
[SPEAKER_00]: So Candida,
[SPEAKER_00]: doesn't just have its cellular form.
[SPEAKER_00]: It will actually team up with other Candida in its high-full forms.
[SPEAKER_00]: I have a whole book on Candida if you're looking into this, but it has almost like a fort.
[SPEAKER_00]: It creates a fort around itself and it protects itself and it can hide out there when you take an anti-fungal if you're taking something.
[SPEAKER_00]: But Burberine actually acts on the biofilm and it attacks the biofilm.
[SPEAKER_00]: So then your immune system can actually access the Candida and clean it up.
[SPEAKER_00]: So that's one of the ways that it impacts Candida.
[SPEAKER_00]: It can also inhibit hyphal morphogenesis.
[SPEAKER_00]: So Candida will move from its cellular form into a hyphal form.
[SPEAKER_00]: And when it's in its hyphal form, it moves around the body and it can create structures.
[SPEAKER_00]: The burbering also negatively impacts Candida's ability to do this as well.
[SPEAKER_00]: It also disrupts something called ergyosterol synthesis.
[SPEAKER_00]: So ergyosterol is the fungal equivalent to cholesterol.
[SPEAKER_00]: If you didn't know cholesterol is also in all of our cell membranes, this is why cholesterol is so misunderstood, we need it, it actually makes your membrane more fluid and more receptive to receptor sites.
[SPEAKER_00]: But Candida doesn't use cholesterol in that way, it uses ergo sterile, which is a different sterile.
[SPEAKER_00]: So cholesterol, ergo sterile.
[SPEAKER_00]: So bebering will impact this as well.
[SPEAKER_00]: Bebering interferes with its synthesis and the same target mechanism as conventional antifungals.
[SPEAKER_00]: Let's finish up the microbiome talk and talk a little bit about the vaginal microbiome.
[SPEAKER_00]: Again, if you're really interested in the vaginal microbiome, I already have a podcast on that if you want to go and listen to that.
[SPEAKER_00]: That is with Dr. Moira.
[SPEAKER_00]: Bradfield straight-em, she's a naturopath who's done her PhD in penile and vaginal microbiomes, and she's very, very interesting and we talk about Candida there as well, but there is a gut vaginal microbiome.
[SPEAKER_00]: So the vaginal microbiome is seated in part from the gut microbiome, and when we see gut dysviosis, we generally see vaginal dysviosis.
[SPEAKER_00]: So people have ABS and IBD, people have CBO, or even high-candida, generally have a gut problem as well.
[SPEAKER_00]: So when we improve gut microbiome diversity and reduce pathogenic bacterial load, my Candida, Virgring can have downstream effects for vaginal microbiome health as well.
[SPEAKER_00]: We also have to understand that our vaginal microbiome is dominated in four out of five women by lactobacillus crispitis, lactobacillus crispitis like school glucose, but if we have two much glucose, it can feed Candida.
[SPEAKER_00]: So this is really fine balance.
[SPEAKER_00]: with how much sugar we want in the vaginal microbiome to feed lactobacillus.
[SPEAKER_00]: And so if we see burberine, as we've been talking about it, it regulates blood sugar.
[SPEAKER_00]: So generally, in women with PMRs, for example, we see really, really high blood glucose because we have insulin resistance and glucose is staying in the bloodstream, which means it's the perfect environment for candida.
[SPEAKER_00]: If we have Burberry in the system working on the gut microbiome, increasing all of these short-chain fatty acids, decreasing gluconeogenesis, decreasing insulin resistance, improving insulin working at the cell, all of these different ways that Burberry works.
[SPEAKER_00]: We will see an improvement in vaginal dysviosis because that is adjusted down from effect of everything that Burberry has done.
[SPEAKER_00]: It's not so much.
[SPEAKER_00]: of a cut and dry berbering, we'll get rid of Candida, berbering will fix or help ameliorate and you negative symptoms that you're having in your vaginal microbiome.
[SPEAKER_00]: It doesn't work that way, it's not that simple.
[SPEAKER_00]: It will kind of set up and reset your body, so you don't have a system that supports dysviosis anymore.
[SPEAKER_00]: So let's talk about who Burberry is best for.
[SPEAKER_00]: You know who it is, it's women with PMOS.
[SPEAKER_00]: So there are estimates that 65 to 80% of people with PMOS have insulin resistance, including those who are linked.
[SPEAKER_00]: So even if you're lean PMOS, you have a risk of having insulin resistance.
[SPEAKER_00]: So insulin resistance is upstream in PMOS.
[SPEAKER_00]: It's not a complication of the condition of most people with PMOS.
[SPEAKER_00]: I say this again and again and again with PMOS.
[SPEAKER_00]: Insulin resistance is not an effect of PMOS.
[SPEAKER_00]: It is the central figure of PMOS, okay?
[SPEAKER_00]: It is not a variant problem.
[SPEAKER_00]: It's not a reproductive problem that happens to impact insulin.
[SPEAKER_00]: It's an insulin cardio-metabolic problem that affects your reproductive tract, okay?
[SPEAKER_00]: So that's how it's working and that's why Berberine is really effective for PMOS,
[SPEAKER_00]: that causes all the problems in PMRS is insulin dysregulation and resistance.
[SPEAKER_00]: Elevated insulin stimulates ovarian thicker cells to produce excess testosterone, which is that hyper-androgenism, which can give you herticism, it can also increase the LH to FSH ratio, driving LH relatively higher, which further stimulates hydrogen production and hybids, follicle maturation.
[SPEAKER_00]: So we have an ovulation and we have more of those possible cysts,
[SPEAKER_00]: Un, uh, ovulated follicles in your ovary.
[SPEAKER_00]: Insulin resistance also impairs progesterone production in the luteofase, because we're not ovulating therefore we're not making a corpus luteium, therefore we're not producing progesterone.
[SPEAKER_00]: It also drives chronic low grade inflammation that characterizes P.M. OS phenotypes.
[SPEAKER_00]: Burberine targets insulin resistance upstream, meaning it addresses the root driver, not just downstream symptoms, which is why evidence-based
[SPEAKER_00]: for Burberry and a PMLS is really, really clinically meaningful, and whoever you're talking to whoever's in your team, a practitioner's at the moment.
[SPEAKER_00]: If you have PMOS or you're suspecting it, I think Bervering should be a conversation that you have with your practitioner and just see how it fits into your protocol.
[SPEAKER_00]: When we look at Bervering in specific PMOS research and outcomes, there are a few things that we want to talk about.
[SPEAKER_00]: So, Android and Reduction.
[SPEAKER_00]: We see a reduction in free testosterone and DHAS.
[SPEAKER_00]: The mechanism that improves insulin sensitivity is also going to reduce the insulin signal that drives ovarian and an Android and production.
[SPEAKER_00]: We're also seeing an improvement in menstrual regularities, so multiple studies show improvements in cycle frequency and regularity.
[SPEAKER_00]: We see an improvement in LHFSH ratio, which means we have better HBO signaling, which means we are actually ovulating.
[SPEAKER_00]: We're seeing improvements in AMH, so some evidence of a reduction in elevated AMH, which is quite classical in PMOS.
[SPEAKER_00]: Again, ovulation rates are improving, so improved ovulation noted in some studies directly relevant to those trying to conceive.
[SPEAKER_00]: In PMOS and Burberry, we also see waste of conference and visceral fat reductions across multiple studies.
[SPEAKER_00]: This is really clinically significant because visceral fat is metabolically active.
[SPEAKER_00]: It produces pro-inflammatory cytokines and it worsens insulin resistance in a self-reinforcing.
[SPEAKER_00]: cycle.
[SPEAKER_00]: So that's really great.
[SPEAKER_00]: We're also seeing Adipoctin, so increased by berbering, and this is really low in PMOS, and its restoration will improve insulin sensitivity and it reduces ovarian inflammation as well.
[SPEAKER_00]: So that's everything we know about PCOS.
[SPEAKER_00]: EMOS, whatever you want to say, and burbring.
[SPEAKER_00]: That's what the research we have again.
[SPEAKER_00]: These studies not really large, not really long, and the generalizability of these studies are questionable, and some of them are better than others.
[SPEAKER_00]: It's a pool of different studies that we're seeing, but it's looking fairly good for the application of PMOS and burbring.
[SPEAKER_00]: What about if you have lean PMOS?
[SPEAKER_00]: What's the deal with that?
[SPEAKER_00]: I think a lot of people think, oh well, I'm lean and I have PMOS, but burberry and helps you lose weight.
[SPEAKER_00]: I don't need any weight lost.
[SPEAKER_00]: So what do I do?
[SPEAKER_00]: Again, burberries affect on weight loss and body composition is moderate in comparison to GLP ones.
[SPEAKER_00]: So there is still an argument for the application of berbering for women who have lean PE or malice.
[SPEAKER_00]: So lean individuals with PE or malice can absolutely have really insumer resistance.
[SPEAKER_00]: It may present differently, so you could have disproportionate central or visceral fat relative to total body weight, a normal fasting glucose that is impaired post-mil glucose clearance is visible on an OGGT or continuous glucose monitor.
[SPEAKER_00]: So basically in English, what does that say?
[SPEAKER_00]: It doesn't really matter.
[SPEAKER_00]: If you have lean PMOS, you still could have a risk of instantly resistance, therefore you could definitely benefit from birboring.
[SPEAKER_00]: One thing I want to say in this podcast, I think there is this nature is better fallacy that's really popular online at the moment.
[SPEAKER_00]: And I think this has just been going on for quite a long time in more wellness circles, and it's this understanding that because it's natural, it's better than everything that's pharmaceutical and therefore it's also safe.
[SPEAKER_00]: That's not the truth.
[SPEAKER_00]: Burberine has risks and we're going to be clearly talking about them now.
[SPEAKER_00]: So if you're on any prescription medication, speak to your doctor or pharmacist before taking Burberine.
[SPEAKER_00]: Please talk to your health practitioner and find a plan if you want to use berbering.
[SPEAKER_00]: This is non-negotiable.
[SPEAKER_00]: If you are taking any medication, please make sure that you talk to them about berbering because it's not inert.
[SPEAKER_00]: It has very clear cut effects on the body that could have negative outcomes for you and your health.
[SPEAKER_00]: Let's talk about pregnancy and breastfeeding.
[SPEAKER_00]: So this is a really firm contradiction.
[SPEAKER_00]: You cannot take berbering when you're breastfeeding and when you are pregnant.
[SPEAKER_00]: Okay?
[SPEAKER_00]: I think a lot of pregnant and breastfeeding women are like add it to the list, you know.
[SPEAKER_00]: So, berbering crosses the placenta in vitro and animal data, uteronic effects, so it stimulates uterine contractions, so there's a risk of miscarriage or preterm labor if you take it during pregnancy.
[SPEAKER_00]: Case reports of neonated jaundance, so berbering displaces bilirubin from Albumin.
[SPEAKER_00]: finding and increases free bill of rubin in newborns, which can cause jaundance and neurological risks, so that's its impacts on your liver.
[SPEAKER_00]: It's also contra-indicated for breastfeeding because berberin has been found in breast milk.
[SPEAKER_00]: So we don't really know how that could affect the baby necessarily.
[SPEAKER_00]: You know, it could be positive, it could be negative, but we just don't have any research on that.
[SPEAKER_00]: So it's totally contra-indicated.
[SPEAKER_00]: So don't take burbering if you're pregnant trying to conceive or breastfeeding without explicit guidance from your treating position.
[SPEAKER_00]: If you're listening to this and you're like, I just did a pregnancy test this morning and found out I'm pregnant.
[SPEAKER_00]: What do I do?
[SPEAKER_00]: You just stop taking burbering, okay?
[SPEAKER_00]: And just tell your physician about it and keep an eye on it.
[SPEAKER_00]: Secondly is your blood glucose lowering medications like metformin.
[SPEAKER_00]: So additive glucose lowering effects could bring you at a higher risk of hypoglycemia, which is really low blood sugar.
[SPEAKER_00]: which means that you have a higher rate of like being fatigued, fatigued, all of these things.
[SPEAKER_00]: So this is not a reason to never combine because there is research out there that suggests that using metformin and berberin at the same time could have positive impacts.
[SPEAKER_00]: But again, this is just something you want to talk to your physician about.
[SPEAKER_00]: CYP enzyme inhibition, so the most clinically significant interactions are here.
[SPEAKER_00]: So berberin inhibits CYP 3A4, CYP 2D6 and CYP C9.
[SPEAKER_00]: So these are the liver's primary side of chrome P450 enzymes responsible for metabolizing large proportions of commonly prescribed drugs.
[SPEAKER_00]: So basically these enzymes break down moist pharmaceutical drugs and burbre in inhibits this.
[SPEAKER_00]: So it means that these drugs sustain your system for longer.
[SPEAKER_00]: So just to give you a bit of a list of possible drug interactions here, so immunosuppressants, statins,
[SPEAKER_00]: Some calcium channel blockers, including diosolum, some benzodiazepines, and some antidepressants and anti-psychotics.
[SPEAKER_00]: So if you're on any type of those drugs, maybe talk to your health provider about it.
[SPEAKER_00]: Coding, to moccasin, SSRIs, also have an impact as well.
[SPEAKER_00]: So these drugs can stay in your system longer if you're taking birboring because birboring inhibits the enzyme that breaks it down in the liver.
[SPEAKER_00]: Let's talk about some other safety considerations again.
[SPEAKER_00]: But just because it's natural doesn't mean it doesn't have risk.
[SPEAKER_00]: So hyperglycemia, even without medications.
[SPEAKER_00]: Okay, so burgreen lowers blood glucose, people who are fast, people who fast, who follow very low carbohydrate diets or exercise intensely should be very, very aware of the additive effects.
[SPEAKER_00]: So shakiness, sweating, brain fog, hunger, dizziness, irritability, and I would also add in some we are I've seen a few reddit threads saying that verb rain made it harder for people to fall asleep and then some people said well I just stopped taking it at dinner time and I saw that it had a better effect but I think that population is quite small and again I haven't looked into that research so that's a risk.
[SPEAKER_00]: G-I side effects, this is the most common one.
[SPEAKER_00]: And people will give up on berbering for this reason, and so nausea, cramping, bloating, diarrhea, and constipation are really, really common and dose dependent.
[SPEAKER_00]: If you are having these impacts, you're taking too much.
[SPEAKER_00]: I think a lot of the time people go, okay, there's amazing RCTs saying to take 1,500 milligrams a day, I'm just going to start with that.
[SPEAKER_00]: And they don't space it out or they just go from taking no berbering.
[SPEAKER_00]: to taking it three times a day.
[SPEAKER_00]: I would really not say that, go really slow.
[SPEAKER_00]: We'll be talking about how to use Burberry in the next section, but that's one of the most common side effects that we see and it's worse in one to two weeks and generally if you go slow, it will go away.
[SPEAKER_00]: So taking with food significantly reduces incidences of these negative GI disturbances and starting low and try trading up really, really helps.
[SPEAKER_00]: So we'll be covering this in a second.
[SPEAKER_00]: microbiome diversity with extended use.
[SPEAKER_00]: So if you're taking it every single day and you're not taking breaks, we can see it has a negative impact on your microbiome diversity in your gut, which is a pretty obvious no bueno, right?
[SPEAKER_00]: So we're seeing a bell curve of effect here.
[SPEAKER_00]: So we're seeing burberrying for a period of time, has a really great impact on your microbiome, and then it starts to go off.
[SPEAKER_00]: with extended use without taking breaks because it's an antimicrobial.
[SPEAKER_00]: Automune conditions as well.
[SPEAKER_00]: So Burbury modulates immune function, and there is theoretical chunks and certain about interactions with older immune conditions.
[SPEAKER_00]: So Hashimoto's, I mean, I could list off all of the different autoimmune conditions, maybe even Epstein bar, could have a negative impact with.
[SPEAKER_00]: But again, the research we have on this is quite limited, and it's theoretical best to talk to your practitioner about this.
[SPEAKER_00]: Finally, let's talk about how we
[SPEAKER_00]: So the evidence based dosing is a standardised dose is 500 milligrams to three times a day with meals.
[SPEAKER_00]: Total daily dose is 1,000 to 1,500 milligrams a day.
[SPEAKER_00]: So taking it with your meals, taking it before your meals.
[SPEAKER_00]: So you're
[SPEAKER_00]: starting protocol generally to reduce the GI side effects is week one is 500 milligrams one daily with your main meal.
[SPEAKER_00]: So I say lunch actually lunch generally should be your biggest meal of the day.
[SPEAKER_00]: I think a lot of people might think breakfast is a little bit easier for them as well.
[SPEAKER_00]: So that's fine.
[SPEAKER_00]: Just either of those is fine.
[SPEAKER_00]: week two, then you move up to two meals a day.
[SPEAKER_00]: So you take it with breakfast and lunch and then wait three, three times a day.
[SPEAKER_00]: Breakfast is lunch dinner.
[SPEAKER_00]: If it starts to impact like you're sleep or you're starting to see hypoglycemia, I would say back off completely talk to someone.
[SPEAKER_00]: But if, you know, you're just starting to see G.I.
[SPEAKER_00]: impacts and things like that, maybe just go down to two days.
[SPEAKER_00]: Just feel it out.
[SPEAKER_00]: Make sure you're consulting your practitioner and keeping them on board so you can figure out what works for you.
[SPEAKER_00]: But generally,
[SPEAKER_00]: The dosing is three weeks and you just for one week, take it once, two weeks, take it twice, three weeks, three, take it three and you're working up to that 1,500 milligram a day, which is evidence based and that's generally what we're seeing.
[SPEAKER_00]: I don't know if they're doing this in the studies actually.
[SPEAKER_00]: When I'm looking at all of these RCTs, I'm wondering if they just get people on to 1,500 milligrams a day because they need to get three months of data out of them or if there's a titration period, I'm going to look into that.
[SPEAKER_00]: I'm fascinated by that.
[SPEAKER_00]: Secondly, cycling.
[SPEAKER_00]: So we really need to cycle, just like Ashwaganda, you need to cycle.
[SPEAKER_00]: So three concerns.
[SPEAKER_00]: So number one, potential intolerance through down regulation of AMPK.
[SPEAKER_00]: We want AMPK to be sensitive for the rest of our life.
[SPEAKER_00]: If you're constantly activating it all time, there is a risk of de-activation and de-sensitization.
[SPEAKER_00]: So we need to take a break for that reason.
[SPEAKER_00]: Microbiome diversity, as we've spoken about multiple times, and lack of long-term safety data in humans beyond six to 12 months.
[SPEAKER_00]: And I would even say, most of the data is three to six
[SPEAKER_00]: So commonly used cycling periods is eight weeks on two to four weeks off and then you come back again and you do eight weeks on so eight weeks on three weeks off eight weeks on three weeks off is generally what people use and using a higher metabolic demand periods so travel eating out higher carbohydrate phases.
[SPEAKER_00]: cycle of during more structured or lower demand periods.
[SPEAKER_00]: So if you want on a holiday to Italy and you're going to be eating pasta three times a day, that could be the time to use birboring and then you just don't use it when you're home.
[SPEAKER_00]: That could be good.
[SPEAKER_00]: But I have to say there is no definitive clinical consensus on cycling these protocols are based on mechanistic reasoning and clinical experience not our CT data, so gotta be really transparent about that again, limitations in research.
[SPEAKER_00]: Next, let's talk about supplement quality because that matters a lot with burberry, so you want to be looking for burberry in HCI, so hydrochloride, this is the most studied form most widely available used in the majority of human RCTs, this is the standard.
[SPEAKER_00]: You want to be also looking for DHB, which has better bioavility, lower dose required fewer GI side effects.
[SPEAKER_00]: It's more expensive, I would say, but it's a good option if standard HCL Burberrying causes persistent gut problems for you, so that's a good option.
[SPEAKER_00]: It's DHB Burberrying.
[SPEAKER_00]: We want to be avoiding products labelled only as Burberrying extract without specifying the salt.
[SPEAKER_00]: that they're using.
[SPEAKER_00]: So is it HCI or is it sulfate?
[SPEAKER_00]: And we also want to be looking at standardization percentages as well.
[SPEAKER_00]: Vague labeling is a really big red flag.
[SPEAKER_00]: So there's a few things you want to look out for.
[SPEAKER_00]: Also alongside that third party testing.
[SPEAKER_00]: So supplement industries have documented quality control problems, heavy metals, incorrect storages, undisclosed fillers, mislabeled ingredients.
[SPEAKER_00]: If you're an allergy girl, you're like fucking, tell me less.
[SPEAKER_00]: I know all
[SPEAKER_00]: think the amount of girls who have gluten or celiac sensitivity and they have been taking a supplement for years and then they find out it has gluten or lactose intolerant people who have been taking supplements for years and then they find out there's lactose supplement industries.
[SPEAKER_00]: They just don't really like to tell you exactly what's in it.
[SPEAKER_00]: So third body testing is always really great because third body testers are never going to be swayed They're always going to tell you this is exactly what's in it and your supplement companies should always be able to provide third party testing Brand recommendations, so this is a straightly accessible and quality verified so thorn and a lot of people like to talk shit about thorn But I don't know why I think they're great and consistently one of the best regarded brands for manufacturing quality and purity testing
[SPEAKER_00]: Their Burberry in 500 heat is widely used in clinical context and it's accessible.
[SPEAKER_00]: Pure encapsulations, it's clean, high-poil and of the genic, if you're an allergy girly, and they have minimal fillers, their third party testing, they're a great option.
[SPEAKER_00]: Integrative therapeutics, a clinical raid, practitioner levels, they're great.
[SPEAKER_00]: Australian practitioner only ranges brands dispense through naturopaths and integrative GP's.
[SPEAKER_00]: So metagenics designs for health and biosidicals.
[SPEAKER_00]: They all have a burberry in each.
[SPEAKER_00]: They all have 500 milligrams generally, and which is really good, and they have high standards, but with that higher cost as well.
[SPEAKER_00]: So I think one of the benefits of metagenics and biosidicals now is I don't think they're naturopathic only, so you can buy them.
[SPEAKER_00]: in health stores and naturopath stores without having to get a script for them anymore, which I think is really, really good.
[SPEAKER_00]: Price here is a quality signal with most supplements it is so expect to pay approximately $40 to $70 a UD, which is pretty good.
[SPEAKER_00]: I would say burberine, most supplements are not really, really affordable, but I mean, it's impacts are really, really great.
[SPEAKER_00]: And thank you so much for listening.
[SPEAKER_00]: I hope you enjoyed this burberine deep dive that we did and you feel a lot more confident in knowing how burbering works in the body,
[SPEAKER_00]: how it impacts the gut and how that's pretty much its central impact on the body and how everything else is really positive outflow from that.
[SPEAKER_00]: If you're interested in the referencing and all of the research that went into this podcast, it's all going to be alongside an article that's posted in my sub-stack or Patreon.
[SPEAKER_00]: So head over there if you're wanting to read more about Burberry and if you're more of a reader then you are a listener.
[SPEAKER_00]: Thank you so much for taking the time out of your busy day to listen to this episode.
[SPEAKER_00]: If you loved it, please remember to like, subscribe, and send to a loved one.
[SPEAKER_00]: If you want to learn more from our quoruman, please check out the website at arquoruman.com.au where you can find a pothora of offerings like charts, masterclasses, courses, and organic clothing.
[SPEAKER_00]: You can also head over to patreon.com slash arquoruman.
[SPEAKER_00]: or sub-stack.com slash alcohol in to join the community.
[SPEAKER_00]: I hope you have a really beautiful morning, afternoon or evening wherever you are in the world, and I will see you on the next episode.