| Team Name | Round | Pick | Overall | Player Name | Position | NFL Team |
| Old England Patriots D | 1 | 1 | 1 | Breece Hall | RB | NYJ |
| Old England Patriots D | 1 | 2 | 2 | Kenneth Walker | RB | SEA |
| Always Next Year | 1 | 3 | 3 | Drake London | WR | ATL |
| rebob | 1 | 4 | 4 | Jameson Williams | WR | DET |
| Cavalry Golden Tanks | 1 | 5 | 5 | Treylon Burks | WR | TEN |
| Cavalry Golden Tanks | 1 | 6 | 6 | Garrett Wilson | WR | NYJ |
| Old England Patriots D | 1 | 7 | 7 | Chris Olave | WR | NO |
| Professor DMX | 1 | 8 | 8 | Dameon Pierce | RB | HOU |
| Pigskin Desperado | 1 | 9 | 9 | James Cook | RB | BUF |
| BOOM Bros | 1 | 10 | 10 | Christian Watson | WR | GB |
| Ball Hogs | 1 | 11 | 11 | Skyy Moore | WR | KC |
| Liar’s Club | 1 | 12 | 12 | Rachaad White | RB | TB |
| Always Next Year | 2 | 1 | 13 | Jahan Dotson | WR | WAS |
| rebob | 2 | 2 | 14 | Tyler Allgeier | RB | ATL |
| Professor DMX | 2 | 3 | 15 | George Pickens | WR | PIT |
| Chicago Playboys | 2 | 4 | 16 | Isaiah Spiller | RB | LAC |
| rebob | 2 | 5 | 17 | Zamir White | RB | LV |
| Take Over 2022 | 2 | 6 | 18 | Calvin Ridley | WR | ATL |
| Ball Hogs | 2 | 7 | 19 | Brian Robinson | RB | WAS |
| Liar’s Club | 2 | 8 | 20 | Trey McBride | TE | ARI |
| Take Over 2022 | 2 | 9 | 21 | Alec Pierce | WR | IND |
| Always Next Year | 2 | 10 | 22 | Albert Okwuegbunam | TE | DEN |
| rebob | 2 | 11 | 23 | Khalil Shakir | WR | BUF |
| Liar’s Club | 2 | 12 | 24 | David Bell | WR | CLE |
| Chicago Playboys | 3 | 1 | 25 | Nyheim Hines | RB | IND |
| rebob | 3 | 2 | 26 | Malik Willis | QB | TEN |
| Always Next Year | 3 | 3 | 27 | Tyrion Davis-Price | RB | SF |
| Professor DMX | 3 | 4 | 28 | John Metchie | WR | HOU |
| Liar’s Club | 3 | 5 | 29 | Pierre Strong | RB | NE |
| Take Over 2022 | 3 | 6 | 30 | Isaih Pacheco | RB | KC |
| Professor DMX | 3 | 7 | 31 | Hayden Hurst | TE | CIN |
| Professor DMX | 3 | 8 | 32 | Robert Tonyan | TE | GB |
| Professor DMX | 3 | 9 | 33 | Kyren Williams | RB | LAR |
| Professor DMX | 3 | 10 | 34 | Velus Jones | WR | CHI |
| Professor DMX | 3 | 11 | 35 | Jalen Tolbert | WR | DAL |
| Liar’s Club | 3 | 12 | 36 | Wan'Dale Robinson | WR | NYG |
| Professor DMX | 4 | 1 | 37 | Devon Williams | WR | BAL |
| Professor DMX | 4 | 2 | 38 | Isaiah Likely | TE | BAL |
| Always Next Year | 4 | 3 | 39 | Taysom Hill | TE | NO |
| Ball Hogs | 4 | 4 | 40 | Marlon Mack | RB | HOU |
| Cavalry Golden Tanks | 4 | 5 | 41 | Joshua Palmer | WR | LAC |
| Take Over 2022 | 4 | 6 | 42 | Romeo Doubs | WR | GB |
| Teutons | 4 | 7 | 43 | DeVante Parker | WR | NE |
| Chicago Playboys | 4 | 8 | 44 | Hassan Haskins | RB | TEN |
| Teutons | 4 | 9 | 45 | Sammy Watkins | WR | GB |
| Teutons | 4 | 10 | 46 | James White | RB | NE |
| Pigskin Desperado | 4 | 11 | 47 | Ke'Shawn Vaughn | RB | TB |
| Liar’s Club | 4 | 12 | 48 | Keaontay Ingram | RB | ARI |
| Take Over 2022 | 5 | 1 | 49 | Snoop Conner | RB | JAC |
| rebob | 5 | 2 | 50 | Greg Dulcich | TE | DEN |
| Always Next Year | 5 | 3 | 51 | Robby Anderson | WR | CAR |
| Ball Hogs | 5 | 4 | 52 | LAC Team Defense | DF | LAC |
| Cavalry Golden Tanks | 5 | 5 | 53 | Jerome Ford | RB | CLE |
| Take Over 2022 | 5 | 6 | 54 | Abram Smith | RB | NO |
| Pigskin Desperado | 5 | 7 | 55 | Curtis Samuel | WR | WAS |
| BOOM Bros | 5 | 8 | 56 | Tyquan Thornton | WR | NE |
| Pigskin Desperado | 5 | 9 | 57 | Sterling Shepard | WR | NYG |
| Teutons | 5 | 10 | 58 | C.J. Uzomah | TE | NYJ |
| BOOM Bros | 5 | 11 | 59 | IND Team Defense | DF | IND |
| Liar’s Club | 5 | 12 | 60 | Jelani Woods | TE | IND |
| Old England Patriots D | 6 | 1 | 61 | Calvin Austin | WR | PIT |
| Take Over 2022 | 6 | 2 | 62 | Kennedy Brooks | RB | PHI |
| Chicago Playboys | 6 | 3 | 63 | Justyn Ross | WR | KC |
| BOOM Bros | 6 | 4 | 64 | Mo Alie-Cox | TE | IND |
| Cavalry Golden Tanks | 6 | 5 | 65 | K.J. Osborn | WR | MIN |
| Take Over 2022 | 6 | 6 | 66 | Kyle Philips | WR | TEN |
| Pigskin Desperado | 6 | 7 | 67 | Kevin Harris | RB | NE |
| Professor DMX | 6 | 8 | 68 | Van Jefferson | WR | LAR |
| Pigskin Desperado | 6 | 9 | 69 | PIT Team Defense | DF | PIT |
| Teutons | 6 | 10 | 70 | Kenyan Drake | RB | LV |
| BOOM Bros | 6 | 11 | 71 | Damien Williams | RB | ATL |
| Liar’s Club | 6 | 12 | 72 | Tyler Badie | RB | BAL |
| Old England Patriots D | 7 | 1 | 73 | Charlie Kolar | TE | BAL |
| rebob | 7 | 2 | 74 | Parris Campbell | WR | IND |
| Always Next Year | 7 | 3 | 75 | Cameron Brate | TE | TB |
| Old England Patriots D | 7 | 4 | 76 | Jameis Winston | QB | NO |
| Cavalry Golden Tanks | 7 | 5 | 77 | Jeremy Ruckert | TE | NYJ |
| Take Over 2022 | 7 | 6 | 78 | Cade Otton | TE | TB |
| Chicago Playboys | 7 | 7 | 79 | Foster Moreau | TE | LV |
| Professor DMX | 7 | 8 | 80 | A.J. Green | WR | ARI |
| Always Next Year | 7 | 9 | 81 | Brandon McManus | PK | DEN |
| Teutons | 7 | 10 | 82 | T.Y. Hilton | WR | FA |
| rebob | 7 | 11 | 83 | Cole Beasley | WR | FA |
| Liar’s Club | 7 | 12 | 84 | Mike Davis | RB | BAL |
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