| Team Name | Round | Pick | Overall | Player Name | Position | NFL Team |
| sHe Hate mE II | 1 | 1 | 1 | Breece Hall | RB | NYJ |
| Lone Wolf | 1 | 2 | 2 | Kenneth Walker | RB | SEA |
| Dynastic II | 1 | 3 | 3 | Drake London | WR | ATL |
| Family Business | 1 | 4 | 4 | Jameson Williams | WR | DET |
| Touchdown Jesus | 1 | 5 | 5 | Treylon Burks | WR | TEN |
| Quad Cities Psychopaths | 1 | 6 | 6 | Chris Olave | WR | NO |
| Catch 22 | 1 | 7 | 7 | Garrett Wilson | WR | NYJ |
| Taco Corp 25 | 1 | 8 | 8 | Skyy Moore | WR | KC |
| I Want Winners! | 1 | 9 | 9 | Christian Watson | WR | GB |
| Touchdown Jesus | 1 | 10 | 10 | James Cook | RB | BUF |
| The Scumpuppies VIII | 1 | 11 | 11 | Jahan Dotson | WR | WAS |
| Sedona Scorpions | 1 | 12 | 12 | George Pickens | WR | PIT |
| I Want Winners! | 2 | 1 | 13 | Isaiah Spiller | RB | LAC |
| Lone Wolf | 2 | 2 | 14 | Alec Pierce | WR | IND |
| Taco Corp 25 | 2 | 3 | 15 | Rachaad White | RB | TB |
| The Scumpuppies VIII | 2 | 4 | 16 | Dameon Pierce | RB | HOU |
| Quad Cities Psychopaths | 2 | 5 | 17 | Trey McBride | TE | ARI |
| Sedona Scorpions | 2 | 6 | 18 | John Metchie | WR | HOU |
| Catch 22 | 2 | 7 | 19 | David Bell | WR | CLE |
| Dynastic II | 2 | 8 | 20 | Zamir White | RB | LV |
| Taco Corp 25 | 2 | 9 | 21 | Tyler Allgeier | RB | ATL |
| Dax | 2 | 10 | 22 | Brian Robinson | RB | WAS |
| The Scumpuppies VIII | 2 | 11 | 23 | Jalen Tolbert | WR | DAL |
| Quad Cities Psychopaths | 2 | 12 | 24 | Allen Lazard | WR | GB |
| Dax | 3 | 1 | 25 | Laviska Shenault | WR | JAC |
| Lone Wolf | 3 | 2 | 26 | Khalil Shakir | WR | BUF |
| I Want Winners! | 3 | 3 | 27 | Gerald Everett | TE | LAC |
| Dax | 3 | 4 | 28 | Malik Willis | QB | TEN |
| Touchdown Jesus | 3 | 5 | 29 | Keaontay Ingram | RB | ARI |
| sHe Hate mE II | 3 | 6 | 30 | Wan'Dale Robinson | WR | NYG |
| Catch 22 | 3 | 7 | 31 | Jelani Woods | TE | IND |
| Dynastic II | 3 | 8 | 32 | Justyn Ross | WR | KC |
| sHe Hate mE II | 3 | 9 | 33 | Tyrion Davis-Price | RB | SF |
| Taco Corp 25 | 3 | 10 | 34 | Calvin Austin | WR | PIT |
| The Scumpuppies VIII | 3 | 11 | 35 | Romeo Doubs | WR | GB |
| Sedona Scorpions | 3 | 12 | 36 | Greg Dulcich | TE | DEN |
| Taco Corp 25 | 4 | 1 | 37 | Trey Sermon | RB | SF |
| Lone Wolf | 4 | 2 | 38 | Jerome Ford | RB | CLE |
| Touchdown Jesus | 4 | 3 | 39 | Hassan Haskins | RB | TEN |
| The Scumpuppies VIII | 4 | 4 | 40 | D'Ernest Johnson | RB | CLE |
| Dynastic II | 4 | 5 | 41 | Austin Hooper | TE | TEN |
| Touchdown Jesus | 4 | 6 | 42 | D'Onta Foreman | RB | CAR |
| Catch 22 | 4 | 7 | 43 | Pierre Strong | RB | NE |
| Dynastic II | 4 | 8 | 44 | Nico Collins | WR | HOU |
| I Want Winners! | 4 | 9 | 45 | Amari Rodgers | WR | GB |
| Lone Wolf | 4 | 10 | 46 | Isaih Pacheco | RB | KC |
| The Scumpuppies VIII | 4 | 11 | 47 | Donovan Peoples-Jones | WR | CLE |
| Sedona Scorpions | 4 | 12 | 48 | Snoop Conner | RB | JAC |
| Taco Corp 25 | 5 | 1 | 49 | Velus Jones | WR | CHI |
| Lone Wolf | 5 | 2 | 50 | Kennedy Brooks | RB | PHI |
| Taco Corp 25 | 5 | 3 | 51 | Gus Edwards | RB | BAL |
| Dax | 5 | 4 | 52 | DeVante Parker | WR | NE |
| Quad Cities Psychopaths | 5 | 5 | 53 | O.J. Howard | TE | BUF |
| Dax | 5 | 6 | 54 | Robby Anderson | WR | CAR |
| Catch 22 | 5 | 7 | 55 | Tyquan Thornton | WR | NE |
| Dynastic II | 5 | 8 | 56 | Cade Otton | TE | TB |
| I Want Winners! | 5 | 9 | 57 | Ke'Shawn Vaughn | RB | TB |
| Family Business | 5 | 10 | 58 | Julio Jones | WR | FA |
| Dax | 5 | 11 | 59 | Kenyan Drake | RB | LV |
| Sedona Scorpions | 5 | 12 | 60 | Zach Wilson | QB | NYJ |
| Touchdown Jesus | 6 | 1 | 61 | Kyren Williams | RB | LAR |
| Lone Wolf | 6 | 2 | 62 | William Fuller | WR | FA |
| Touchdown Jesus | 6 | 3 | 63 | Kirk Cousins | QB | MIN |
| Dax | 6 | 4 | 64 | Corey Davis | WR | NYJ |
| Quad Cities Psychopaths | 6 | 5 | 65 | Tyler Badie | RB | BAL |
| I Want Winners! | 6 | 6 | 66 | DEN Team Defense | DF | DEN |
| Catch 22 | 6 | 7 | 67 | Curtis Samuel | WR | WAS |
| Dynastic II | 6 | 8 | 68 | Kylen Granson | TE | IND |
| I Want Winners! | 6 | 9 | 69 | Kenny Pickett | QB | PIT |
| Touchdown Jesus | 6 | 10 | 70 | Abram Smith | RB | NO |
| The Scumpuppies VIII | 6 | 11 | 71 | Kevin Harris | RB | NE |
| The Scumpuppies VIII | 6 | 12 | 72 | LAC Team Defense | DF | LAC |
| sHe Hate mE II | 7 | 1 | 73 | Kevin Austin | WR | JAC |
| Lone Wolf | 7 | 2 | 74 | Mark Ingram | RB | NO |
| Taco Corp 25 | 7 | 3 | 75 | Harrison Bryant | TE | CLE |
| Dax | 7 | 4 | 76 | Isaiah Likely | TE | BAL |
| Quad Cities Psychopaths | 7 | 5 | 77 | Damien Williams | RB | ATL |
| I Want Winners! | 7 | 6 | 78 | KJ Hamler | WR | DEN |
| Catch 22 | 7 | 7 | 79 | Tony Jones | RB | NO |
| Dynastic II | 7 | 8 | 80 | Jacob Harris | TE | LAR |
| I Want Winners! | 7 | 9 | 81 | Samaje Perine | RB | CIN |
| Touchdown Jesus | 7 | 10 | 82 | Mo Alie-Cox | TE | IND |
| The Scumpuppies VIII | 7 | 11 | 83 | Tyler Huntley | QB | BAL |
| Sedona Scorpions | 7 | 12 | 84 | ZaQuandre White | RB | FA |
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