| Team Name | Round | Pick | Overall | Player Name | Position | NFL Team |
| Almost Famous | 1 | 1 | 1 | Breece Hall | RB | NYJ |
| A.A.1250.21 | 1 | 2 | 2 | Kenneth Walker | RB | SEA |
| The Champs 21 | 1 | 3 | 3 | Drake London | WR | ATL |
| Almost Famous | 1 | 4 | 4 | Jameson Williams | WR | DET |
| PJSalt Dynasty 1250 Rebuild | 1 | 5 | 5 | Treylon Burks | WR | TEN |
| Kicker Lives Matter | 1 | 6 | 6 | Garrett Wilson | WR | NYJ |
| Almost Famous | 1 | 7 | 7 | Christian Watson | WR | GB |
| KBLJ | 1 | 8 | 8 | Chris Olave | WR | NO |
| A.A.1250.21 | 1 | 9 | 9 | Skyy Moore | WR | KC |
| Almost Famous | 1 | 10 | 10 | James Cook | RB | BUF |
| Taco Corp 21 | 1 | 11 | 11 | Jahan Dotson | WR | WAS |
| Cat-Like Reflexes | 1 | 12 | 12 | Isaiah Spiller | RB | LAC |
| The Champs 21 | 2 | 1 | 13 | Rachaad White | RB | TB |
| The Champs 21 | 2 | 2 | 14 | George Pickens | WR | PIT |
| Kicker Lives Matter | 2 | 3 | 15 | Brian Robinson | RB | WAS |
| Cheeseheads | 2 | 4 | 16 | Dameon Pierce | RB | HOU |
| Taco Corp 21 | 2 | 5 | 17 | Trey McBride | TE | ARI |
| KBLJ | 2 | 6 | 18 | Zamir White | RB | LV |
| Taco Corp 21 | 2 | 7 | 19 | Tyrion Davis-Price | RB | SF |
| Kicker Lives Matter | 2 | 8 | 20 | John Metchie | WR | HOU |
| Cat-Like Reflexes | 2 | 9 | 21 | Justyn Ross | WR | KC |
| DOC16 | 2 | 10 | 22 | Alec Pierce | WR | IND |
| Taco Corp 21 | 2 | 11 | 23 | Tyler Allgeier | RB | ATL |
| Cat-Like Reflexes | 2 | 12 | 24 | David Bell | WR | CLE |
| Taco Corp 21 | 3 | 1 | 25 | Wan'Dale Robinson | WR | NYG |
| The Champs 21 | 3 | 2 | 26 | Cordarrelle Patterson | RB | ATL |
| A.A.1250.21 | 3 | 3 | 27 | Jalen Tolbert | WR | DAL |
| Cheeseheads | 3 | 4 | 28 | Keaontay Ingram | RB | ARI |
| PJSalt Dynasty 1250 Rebuild | 3 | 5 | 29 | Pierre Strong | RB | NE |
| KBLJ | 3 | 6 | 30 | Marlon Mack | RB | HOU |
| Cheeseheads | 3 | 7 | 31 | Khalil Shakir | WR | BUF |
| Almost Famous | 3 | 8 | 32 | Jelani Woods | TE | IND |
| Cat-Like Reflexes | 3 | 9 | 33 | Sony Michel | RB | MIA |
| Shef's Punishers D1250 | 3 | 10 | 34 | Calvin Austin | WR | PIT |
| DOC16 | 3 | 11 | 35 | Marquez Valdes-Scantling | WR | KC |
| Almost Famous | 3 | 12 | 36 | Romeo Doubs | WR | GB |
| Taco Corp 21 | 4 | 1 | 37 | Robert Tonyan | TE | GB |
| The Champs 21 | 4 | 2 | 38 | Tyquan Thornton | WR | NE |
| A.A.1250.21 | 4 | 3 | 39 | Corey Davis | WR | NYJ |
| Cheeseheads | 4 | 4 | 40 | Kyren Williams | RB | LAR |
| Cheeseheads | 4 | 5 | 41 | Greg Dulcich | TE | DEN |
| KBLJ | 4 | 6 | 42 | Hayden Hurst | TE | CIN |
| Taco Corp 21 | 4 | 7 | 43 | Velus Jones | WR | CHI |
| Cat-Like Reflexes | 4 | 8 | 44 | Jerome Ford | RB | CLE |
| Taco Corp 21 | 4 | 9 | 45 | Hassan Haskins | RB | TEN |
| Shef's Punishers D1250 | 4 | 10 | 46 | Austin Hooper | TE | TEN |
| Shef's Punishers D1250 | 4 | 11 | 47 | Adam Trautman | TE | NO |
| Almost Famous | 4 | 12 | 48 | Brevin Jordan | TE | HOU |
| Kicker Lives Matter | 5 | 1 | 49 | Derek Carr | QB | LV |
| The Champs 21 | 5 | 2 | 50 | Sammy Watkins | WR | GB |
| A.A.1250.21 | 5 | 3 | 51 | Tyler Badie | RB | BAL |
| Cheeseheads | 5 | 4 | 52 | Harrison Butker | PK | KC |
| PJSalt Dynasty 1250 Rebuild | 5 | 5 | 53 | Malik Willis | QB | TEN |
| KBLJ | 5 | 6 | 54 | Kirk Cousins | QB | MIN |
| Taco Corp 21 | 5 | 7 | 55 | Joshua Palmer | WR | LAC |
| Cat-Like Reflexes | 5 | 8 | 56 | Amari Rodgers | WR | GB |
| Lux Dynasty | 5 | 9 | 57 | Chuba Hubbard | RB | CAR |
| Shef's Punishers D1250 | 5 | 10 | 58 | KJ Hamler | WR | DEN |
| Shef's Punishers D1250 | 5 | 11 | 59 | Eno Benjamin | RB | ARI |
| Almost Famous | 5 | 12 | 60 | Snoop Conner | RB | JAC |
| Kicker Lives Matter | 6 | 1 | 61 | Foster Moreau | TE | LV |
| The Champs 21 | 6 | 2 | 62 | Julio Jones | WR | FA |
| A.A.1250.21 | 6 | 3 | 63 | Zach Wilson | QB | NYJ |
| Cheeseheads | 6 | 4 | 64 | Tim Patrick | WR | DEN |
| PJSalt Dynasty 1250 Rebuild | 6 | 5 | 65 | Kevin Harris | RB | NE |
| KBLJ | 6 | 6 | 66 | MIA Team Defense | DF | MIA |
| Taco Corp 21 | 6 | 7 | 67 | Cade Otton | TE | TB |
| Cat-Like Reflexes | 6 | 8 | 68 | Chris Evans | RB | CIN |
| Lux Dynasty | 6 | 9 | 69 | Derrius Guice | RB | FA |
| Kicker Lives Matter | 6 | 10 | 70 | Cade York | PK | CLE |
| Taco Corp 21 | 6 | 11 | 71 | Bryan Edwards | WR | LV |
| DOC16 | 6 | 12 | 72 | Isaiah Likely | TE | BAL |
| Kicker Lives Matter | 7 | 1 | 73 | Taysom Hill | TE | NO |
| KBLJ | 7 | 2 | 74 | Jason Sanders | PK | MIA |
| A.A.1250.21 | 7 | 3 | 75 | PIT Team Defense | DF | PIT |
| The Champs 21 | 7 | 4 | 76 | Isaih Pacheco | RB | KC |
| PJSalt Dynasty 1250 Rebuild | 7 | 5 | 77 | Jalen Wydermyer | TE | FA |
| KBLJ | 7 | 6 | 78 | Kenny Pickett | QB | PIT |
| Taco Corp 21 | 7 | 7 | 79 | Harrison Bryant | TE | CLE |
| Lux Dynasty | 7 | 8 | 80 | Mo Alie-Cox | TE | IND |
| DOC16 | 7 | 9 | 81 | Devin Duvernay | WR | BAL |
| Shef's Punishers D1250 | 7 | 10 | 82 | Damien Williams | RB | ATL |
| Lux Dynasty | 7 | 11 | 83 | Abram Smith | RB | NO |
| DOC16 | 7 | 12 | 84 | Mike Davis | RB | BAL |
