| Team Name | Round | Pick | Overall | Player Name | Position | NFL Team |
| Bad Things | 1 | 1 | 1 | Breece Hall | RB | NYJ |
| The Viltrumites 3.0 | 1 | 2 | 2 | Kenneth Walker | RB | SEA |
| Bad Things | 1 | 3 | 3 | Treylon Burks | WR | TEN |
| Night Owls F22 | 1 | 4 | 4 | Drake London | WR | ATL |
| El Rey | 1 | 5 | 5 | Garrett Wilson | WR | NYJ |
| Wasp DieNasty II | 1 | 6 | 6 | Jameson Williams | WR | DET |
| Wasp DieNasty II | 1 | 7 | 7 | Skyy Moore | WR | KC |
| vcstaff | 1 | 8 | 8 | Chris Olave | WR | NO |
| Motor City Kitties | 1 | 9 | 9 | James Cook | RB | BUF |
| TheMagicRonJon | 1 | 10 | 10 | Christian Watson | WR | GB |
| Highseas Knights | 1 | 11 | 11 | Rachaad White | RB | TB |
| Reverend Ray Nitschke | 1 | 12 | 12 | George Pickens | WR | PIT |
| The Viltrumites 3.0 | 2 | 1 | 13 | Dameon Pierce | RB | HOU |
| The Viltrumites 3.0 | 2 | 2 | 14 | David Bell | WR | CLE |
| Bad Things | 2 | 3 | 15 | Albert Okwuegbunam | TE | DEN |
| Night Owls F22 | 2 | 4 | 16 | Jahan Dotson | WR | WAS |
| El Rey | 2 | 5 | 17 | Tyler Allgeier | RB | ATL |
| Reverend Ray Nitschke | 2 | 6 | 18 | Isaiah Spiller | RB | LAC |
| The Viltrumites 3.0 | 2 | 7 | 19 | Trey McBride | TE | ARI |
| Night Owls F22 | 2 | 8 | 20 | Zamir White | RB | LV |
| Reverend Ray Nitschke | 2 | 9 | 21 | John Metchie | WR | HOU |
| TheMagicRonJon | 2 | 10 | 22 | Pierre Strong | RB | NE |
| Highseas Knights | 2 | 11 | 23 | Brian Robinson | RB | WAS |
| Red Bulls | 2 | 12 | 24 | Alec Pierce | WR | IND |
| Reverend Ray Nitschke | 3 | 1 | 25 | Wan'Dale Robinson | WR | NYG |
| Motor City Kitties | 3 | 2 | 26 | Robert Tonyan | TE | GB |
| Bad Things | 3 | 3 | 27 | Evan Engram | TE | JAC |
| Night Owls F22 | 3 | 4 | 28 | Jerome Ford | RB | CLE |
| Red Bulls | 3 | 5 | 29 | Jalen Tolbert | WR | DAL |
| Red Bulls | 3 | 6 | 30 | Tyrion Davis-Price | RB | SF |
| El Rey | 3 | 7 | 31 | Romeo Doubs | WR | GB |
| El Rey | 3 | 8 | 32 | Hayden Hurst | TE | CIN |
| Red Bulls | 3 | 9 | 33 | Jelani Woods | TE | IND |
| TheMagicRonJon | 3 | 10 | 34 | Khalil Shakir | WR | BUF |
| Wasp DieNasty II | 3 | 11 | 35 | Kenny Pickett | QB | PIT |
| Reverend Ray Nitschke | 3 | 12 | 36 | Justyn Ross | WR | KC |
| The Viltrumites 3.0 | 4 | 1 | 37 | DeVante Parker | WR | NE |
| Red Bulls | 4 | 2 | 38 | Allen Lazard | WR | GB |
| Bad Things | 4 | 3 | 39 | Curtis Samuel | WR | WAS |
| Night Owls F22 | 4 | 4 | 40 | Russell Gage | WR | TB |
| Red Bulls | 4 | 5 | 41 | Joshua Palmer | WR | LAC |
| Holly's Sweet Brown Panda | 4 | 6 | 42 | Tyler Higbee | TE | LAR |
| Wasp DieNasty II | 4 | 7 | 43 | Mecole Hardman | WR | KC |
| Holly's Sweet Brown Panda | 4 | 8 | 44 | Mark Ingram | RB | NO |
| Holly's Sweet Brown Panda | 4 | 9 | 45 | IND Team Defense | DF | IND |
| TheMagicRonJon | 4 | 10 | 46 | Jakobi Meyers | WR | NE |
| Reverend Ray Nitschke | 4 | 11 | 47 | Hassan Haskins | RB | TEN |
| vcstaff | 4 | 12 | 48 | Nyheim Hines | RB | IND |
| El Rey | 5 | 1 | 49 | Zach Wilson | QB | NYJ |
| Motor City Kitties | 5 | 2 | 50 | D'Onta Foreman | RB | CAR |
| Bad Things | 5 | 3 | 51 | Austin Hooper | TE | TEN |
| Night Owls F22 | 5 | 4 | 52 | Malik Willis | QB | TEN |
| The Viltrumites 3.0 | 5 | 5 | 53 | Tyquan Thornton | WR | NE |
| vcstaff | 5 | 6 | 54 | Greg Dulcich | TE | DEN |
| Wasp DieNasty II | 5 | 7 | 55 | Velus Jones | WR | CHI |
| Holly's Sweet Brown Panda | 5 | 8 | 56 | Devin Duvernay | WR | BAL |
| Reverend Ray Nitschke | 5 | 9 | 57 | Ty Chandler | RB | MIN |
| Red Bulls | 5 | 10 | 58 | Keaontay Ingram | RB | ARI |
| Red Bulls | 5 | 11 | 59 | K.J. Osborn | WR | MIN |
| vcstaff | 5 | 12 | 60 | Harrison Bryant | TE | CLE |
| El Rey | 6 | 1 | 61 | Taysom Hill | TE | NO |
| Motor City Kitties | 6 | 2 | 62 | Marvin Jones | WR | JAC |
| Bad Things | 6 | 3 | 63 | Donovan Peoples-Jones | WR | CLE |
| Night Owls F22 | 6 | 4 | 64 | Kevin Harris | RB | NE |
| Highseas Knights | 6 | 5 | 65 | Kyren Williams | RB | LAR |
| vcstaff | 6 | 6 | 66 | Calvin Austin | WR | PIT |
| Wasp DieNasty II | 6 | 7 | 67 | Marlon Mack | RB | HOU |
| Highseas Knights | 6 | 8 | 68 | Chuba Hubbard | RB | CAR |
| Red Bulls | 6 | 9 | 69 | Tyler Badie | RB | BAL |
| TheMagicRonJon | 6 | 10 | 70 | LAR Team Defense | DF | LAR |
| Holly's Sweet Brown Panda | 6 | 11 | 71 | Gus Edwards | RB | BAL |
| Red Bulls | 6 | 12 | 72 | Mac Jones | QB | NE |
| El Rey | 7 | 1 | 73 | Eno Benjamin | RB | ARI |
| Motor City Kitties | 7 | 2 | 74 | Darrel Williams | RB | KC |
| Bad Things | 7 | 3 | 75 | Nelson Agholor | WR | NE |
| Night Owls F22 | 7 | 4 | 76 | Ryan Tannehill | QB | TEN |
| The Viltrumites 3.0 | 7 | 5 | 77 | PIT Team Defense | DF | PIT |
| Highseas Knights | 7 | 6 | 78 | Desmond Ridder | QB | ATL |
| Wasp DieNasty II | 7 | 7 | 79 | Ke'Shawn Vaughn | RB | TB |
| Red Bulls | 7 | 8 | 80 | Isaih Pacheco | RB | KC |
| Reverend Ray Nitschke | 7 | 9 | 81 | Snoop Conner | RB | JAC |
| TheMagicRonJon | 7 | 10 | 82 | LAC Team Defense | DF | LAC |
| Holly's Sweet Brown Panda | 7 | 11 | 83 | C.J. Uzomah | TE | NYJ |
| vcstaff | 7 | 12 | 84 | Jamison Crowder | WR | BUF |
