| Team Name | Round | Pick | Overall | Player Name | Position | NFL Team |
| Red Dog Rudy #5 ($77/120d)** | 1 | 1 | 1 | Breece Hall | RB | NYJ |
| Drunken Puppets | 1 | 2 | 2 | Drake London | WR | ATL |
| Broken Tables | 1 | 3 | 3 | Garrett Wilson | WR | NYJ |
| DynoRex | 1 | 4 | 4 | Treylon Burks | WR | TEN |
| The Program | 1 | 5 | 5 | Kenneth Walker | RB | SEA |
| Broken Tables | 1 | 6 | 6 | Jameson Williams | WR | DET |
| Dollar Bill dynasty 5 | 1 | 7 | 7 | Skyy Moore | WR | KC |
| Bentley Bros | 1 | 8 | 8 | Christian Watson | WR | GB |
| Steel Curtain #5/$77 | 1 | 9 | 9 | Chris Olave | WR | NO |
| Nigh Owls F113 | 1 | 10 | 10 | George Pickens | WR | PIT |
| Broken Tables | 1 | 11 | 11 | Isaiah Spiller | RB | LAC |
| Gobblers #5/2021 | 1 | 12 | 12 | Dameon Pierce | RB | HOU |
| Dollar Bill dynasty 5 | 2 | 1 | 13 | James Cook | RB | BUF |
| Nigh Owls F113 | 2 | 2 | 14 | Jahan Dotson | WR | WAS |
| Genada | 2 | 3 | 15 | Brian Robinson | RB | WAS |
| The Program | 2 | 4 | 16 | John Metchie | WR | HOU |
| Nigh Owls F113 | 2 | 5 | 17 | Rachaad White | RB | TB |
| Broken Tables | 2 | 6 | 18 | Zamir White | RB | LV |
| Dollar Bill dynasty 5 | 2 | 7 | 19 | Trey McBride | TE | ARI |
| Bentley Bros | 2 | 8 | 20 | Tyler Allgeier | RB | ATL |
| Steel Curtain #5/$77 | 2 | 9 | 21 | Irv Smith | TE | MIN |
| The Program | 2 | 10 | 22 | Kenny Pickett | QB | PIT |
| Broken Tables | 2 | 11 | 23 | Albert Okwuegbunam | TE | DEN |
| The Program | 2 | 12 | 24 | David Bell | WR | CLE |
| Nigh Owls F113 | 3 | 1 | 25 | Pierre Strong | RB | NE |
| Gobblers #5/2021 | 3 | 2 | 26 | Kyren Williams | RB | LAR |
| Steel Curtain #5/$77 | 3 | 3 | 27 | Ronald Jones | RB | KC |
| Gobblers #5/2021 | 3 | 4 | 28 | Alec Pierce | WR | IND |
| Red Dog Rudy #5 ($77/120d)** | 3 | 5 | 29 | Nyheim Hines | RB | IND |
| Broken Tables | 3 | 6 | 30 | Keaontay Ingram | RB | ARI |
| Dollar Bill dynasty 5 | 3 | 7 | 31 | Jalen Tolbert | WR | DAL |
| Bentley Bros | 3 | 8 | 32 | Raheem Mostert | RB | MIA |
| The Program | 3 | 9 | 33 | Wan'Dale Robinson | WR | NYG |
| The Program | 3 | 10 | 34 | Malik Willis | QB | TEN |
| Broken Tables | 3 | 11 | 35 | Isaiah Likely | TE | BAL |
| Gobblers #5/2021 | 3 | 12 | 36 | Khalil Shakir | WR | BUF |
| Steel Curtain #5/$77 | 4 | 1 | 37 | Hassan Haskins | RB | TEN |
| Steel Curtain #5/$77 | 4 | 2 | 38 | Derek Carr | QB | LV |
| Genada | 4 | 3 | 39 | Marlon Mack | RB | HOU |
| DynoRex | 4 | 4 | 40 | Tyrion Davis-Price | RB | SF |
| The Program | 4 | 5 | 41 | Allen Lazard | WR | GB |
| Broken Tables | 4 | 6 | 42 | Jerome Ford | RB | CLE |
| Dollar Bill dynasty 5 | 4 | 7 | 43 | Tyquan Thornton | WR | NE |
| Bentley Bros | 4 | 8 | 44 | D'Onta Foreman | RB | CAR |
| DynoRex | 4 | 9 | 45 | Justin Fields | QB | CHI |
| The Program | 4 | 10 | 46 | Mike Davis | RB | FA |
| Broken Tables | 4 | 11 | 47 | Isaih Pacheco | RB | KC |
| Gobblers #5/2021 | 4 | 12 | 48 | Hayden Hurst | TE | CIN |
| American SLAD-iators | 5 | 1 | 49 | Ryan Tannehill | QB | TEN |
| Drunken Puppets | 5 | 2 | 50 | DJ Chark | WR | DET |
| Genada | 5 | 3 | 51 | Ke'Shawn Vaughn | RB | TB |
| DynoRex | 5 | 4 | 52 | Jelani Woods | TE | IND |
| Red Dog Rudy #5 ($77/120d)** | 5 | 5 | 53 | J.D. McKissic | RB | WAS |
| Broken Tables | 5 | 6 | 54 | MIA Team Defense | DF | MIA |
| Dollar Bill dynasty 5 | 5 | 7 | 55 | Jakobi Meyers | WR | NE |
| Bentley Bros | 5 | 8 | 56 | Jameis Winston | QB | NO |
| American SLAD-iators | 5 | 9 | 57 | K.J. Osborn | WR | MIN |
| American SLAD-iators | 5 | 10 | 58 | Austin Hooper | TE | TEN |
| Gobblers #5/2021 | 5 | 11 | 59 | Laviska Shenault | WR | JAC |
| Gobblers #5/2021 | 5 | 12 | 60 | Parris Campbell | WR | IND |
| Steel Curtain #5/$77 | 6 | 1 | 61 | Justyn Ross | WR | KC |
| Drunken Puppets | 6 | 2 | 62 | Calvin Austin | WR | PIT |
| Genada | 6 | 3 | 63 | Kennedy Brooks | RB | PHI |
| DynoRex | 6 | 4 | 64 | William Fuller | WR | FA |
| Red Dog Rudy #5 ($77/120d)** | 6 | 5 | 65 | Curtis Samuel | WR | WAS |
| Red Dog Rudy #5 ($77/120d)** | 6 | 6 | 66 | Gerald Everett | TE | LAC |
| Dollar Bill dynasty 5 | 6 | 7 | 67 | Tyler Badie | RB | BAL |
| Bentley Bros | 6 | 8 | 68 | IND Team Defense | DF | IND |
| Steel Curtain #5/$77 | 6 | 9 | 69 | Greg Dulcich | TE | DEN |
| American SLAD-iators | 6 | 10 | 70 | Eno Benjamin | RB | ARI |
| Steel Curtain #5/$77 | 6 | 11 | 71 | Romeo Doubs | WR | GB |
| Gobblers #5/2021 | 6 | 12 | 72 | Chris Evans | RB | CIN |
| Nigh Owls F113 | 7 | 1 | 73 | Logan Thomas | TE | WAS |
| Drunken Puppets | 7 | 2 | 74 | Jamaal Williams | RB | DET |
| Genada | 7 | 3 | 75 | Donovan Peoples-Jones | WR | CLE |
| DynoRex | 7 | 4 | 76 | Matt Ryan | QB | IND |
| Red Dog Rudy #5 ($77/120d)** | 7 | 5 | 77 | Daniel Jones | QB | NYG |
| Gobblers #5/2021 | 7 | 6 | 78 | Kevin Harris | RB | NE |
| Dollar Bill dynasty 5 | 7 | 7 | 79 | D'Ernest Johnson | RB | CLE |
| Bentley Bros | 7 | 8 | 80 | KJ Hamler | WR | DEN |
| Steel Curtain #5/$77 | 7 | 9 | 81 | Jared Goff | QB | DET |
| Steel Curtain #5/$77 | 7 | 10 | 82 | Kenyan Drake | RB | LV |
| Red Dog Rudy #5 ($77/120d)** | 7 | 11 | 83 | Matt Breida | RB | NYG |
| Gobblers #5/2021 | 7 | 12 | 84 | Desmond Ridder | QB | ATL |
