| Team Name | Round | Pick | Overall | Player Name | Position | NFL Team |
| russnuss | 1 | 1 | 1 | Josh Allen | QB | BUF |
| StitchCurry | 1 | 2 | 2 | Justin Herbert | QB | LAC |
| Hammers 89 | 1 | 3 | 3 | Patrick Mahomes | QB | KC |
| Lucky 3s | 1 | 4 | 4 | Jonathan Taylor | RB | IND |
| Fly | 1 | 5 | 5 | Lamar Jackson | QB | BAL |
| Team XXX | 1 | 6 | 6 | Cooper Kupp | WR | LAR |
| OTLY | 1 | 7 | 7 | Kyler Murray | QB | ARI |
| Sports Doctor SFBB21* | 1 | 8 | 8 | Joe Burrow | QB | CIN |
| LetsGo!!! | 1 | 9 | 9 | Christian McCaffrey | RB | CAR |
| Prometheus | 1 | 10 | 10 | Russell Wilson | QB | DEN |
| SF10 | 1 | 11 | 11 | Travis Kelce | TE | KC |
| WHAT A WASTE | 1 | 12 | 12 | Dak Prescott | QB | DAL |
| WHAT A WASTE | 2 | 1 | 13 | Tom Brady | QB | TB |
| SF10 | 2 | 2 | 14 | Austin Ekeler | RB | LAC |
| Prometheus | 2 | 3 | 15 | Jalen Hurts | QB | PHI |
| LetsGo!!! | 2 | 4 | 16 | Justin Jefferson | WR | MIN |
| Sports Doctor SFBB21* | 2 | 5 | 17 | Trey Lance | QB | SF |
| OTLY | 2 | 6 | 18 | Ja'Marr Chase | WR | CIN |
| Team XXX | 2 | 7 | 19 | Matthew Stafford | QB | LAR |
| Fly | 2 | 8 | 20 | Derek Carr | QB | LV |
| Lucky 3s | 2 | 9 | 21 | Aaron Rodgers | QB | GB |
| Hammers 89 | 2 | 10 | 22 | Najee Harris | RB | PIT |
| StitchCurry | 2 | 11 | 23 | Derrick Henry | RB | TEN |
| russnuss | 2 | 12 | 24 | Mark Andrews | TE | BAL |
| russnuss | 3 | 1 | 25 | Stefon Diggs | WR | BUF |
| StitchCurry | 3 | 2 | 26 | Dalvin Cook | RB | MIN |
| Hammers 89 | 3 | 3 | 27 | CeeDee Lamb | WR | DAL |
| Lucky 3s | 3 | 4 | 28 | Kirk Cousins | QB | MIN |
| Fly | 3 | 5 | 29 | Davante Adams | WR | LV |
| Team XXX | 3 | 6 | 30 | Joe Mixon | RB | CIN |
| OTLY | 3 | 7 | 31 | Tua Tagovailoa | QB | MIA |
| Sports Doctor SFBB21* | 3 | 8 | 32 | Kyle Pitts | TE | ATL |
| LetsGo!!! | 3 | 9 | 33 | Justin Fields | QB | CHI |
| Prometheus | 3 | 10 | 34 | D'Andre Swift | RB | DET |
| SF10 | 3 | 11 | 35 | Saquon Barkley | RB | NYG |
| WHAT A WASTE | 3 | 12 | 36 | Matt Ryan | QB | IND |
| WHAT A WASTE | 4 | 1 | 37 | Daniel Jones | QB | NYG |
| SF10 | 4 | 2 | 38 | Jameis Winston | QB | NO |
| Prometheus | 4 | 3 | 39 | Trevor Lawrence | QB | JAC |
| LetsGo!!! | 4 | 4 | 40 | Aaron Jones | RB | GB |
| Sports Doctor SFBB21* | 4 | 5 | 41 | Alvin Kamara | RB | NO |
| OTLY | 4 | 6 | 42 | Javonte Williams | RB | DEN |
| Team XXX | 4 | 7 | 43 | Jared Goff | QB | DET |
| Fly | 4 | 8 | 44 | Darren Waller | TE | LV |
| Lucky 3s | 4 | 9 | 45 | Zach Wilson | QB | NYJ |
| Hammers 89 | 4 | 10 | 46 | Mac Jones | QB | NE |
| StitchCurry | 4 | 11 | 47 | Deebo Samuel | WR | SF |
| russnuss | 4 | 12 | 48 | Leonard Fournette | RB | TB |
| russnuss | 5 | 1 | 49 | Tee Higgins | WR | CIN |
| StitchCurry | 5 | 2 | 50 | Ryan Tannehill | QB | TEN |
| Hammers 89 | 5 | 3 | 51 | Breece Hall | RB | NYJ |
| Lucky 3s | 5 | 4 | 52 | Nick Chubb | RB | CLE |
| Fly | 5 | 5 | 53 | Mike Evans | WR | TB |
| Team XXX | 5 | 6 | 54 | Keenan Allen | WR | LAC |
| OTLY | 5 | 7 | 55 | Tyreek Hill | WR | MIA |
| Sports Doctor SFBB21* | 5 | 8 | 56 | George Kittle | TE | SF |
| LetsGo!!! | 5 | 9 | 57 | James Conner | RB | ARI |
| Prometheus | 5 | 10 | 58 | Michael Pittman | WR | IND |
| SF10 | 5 | 11 | 59 | Davis Mills | QB | HOU |
| WHAT A WASTE | 5 | 12 | 60 | Baker Mayfield | QB | CAR |
| WHAT A WASTE | 6 | 1 | 61 | A.J. Brown | WR | PHI |
| SF10 | 6 | 2 | 62 | Travis Etienne | RB | JAC |
| Prometheus | 6 | 3 | 63 | Ezekiel Elliott | RB | DAL |
| LetsGo!!! | 6 | 4 | 64 | David Montgomery | RB | CHI |
| Sports Doctor SFBB21* | 6 | 5 | 65 | Diontae Johnson | WR | PIT |
| OTLY | 6 | 6 | 66 | Mike Williams | WR | LAC |
| Team XXX | 6 | 7 | 67 | T.J. Hockenson | TE | DET |
| Fly | 6 | 8 | 68 | J.K. Dobbins | RB | BAL |
| Lucky 3s | 6 | 9 | 69 | DJ Moore | WR | CAR |
| Hammers 89 | 6 | 10 | 70 | Carson Wentz | QB | WAS |
| StitchCurry | 6 | 11 | 71 | Cam Akers | RB | LAR |
| russnuss | 6 | 12 | 72 | Jaylen Waddle | WR | MIA |
| russnuss | 7 | 1 | 73 | Marcus Mariota | QB | ATL |
| StitchCurry | 7 | 2 | 74 | Terry McLaurin | WR | WAS |
| Hammers 89 | 7 | 3 | 75 | Dalton Schultz | TE | DAL |
| Lucky 3s | 7 | 4 | 76 | Allen Robinson | WR | LAR |
| Fly | 7 | 5 | 77 | Courtland Sutton | WR | DEN |
| Team XXX | 7 | 6 | 78 | Amon-Ra St. Brown | WR | DET |
| OTLY | 7 | 7 | 79 | Brandin Cooks | WR | HOU |
| Sports Doctor SFBB21* | 7 | 8 | 80 | Marquise Brown | WR | ARI |
| LetsGo!!! | 7 | 9 | 81 | JuJu Smith-Schuster | WR | KC |
| Prometheus | 7 | 10 | 82 | Dallas Goedert | TE | PHI |
| SF10 | 7 | 11 | 83 | Chris Godwin | WR | TB |
| WHAT A WASTE | 7 | 12 | 84 | Josh Jacobs | RB | LV |
| WHAT A WASTE | 8 | 1 | 85 | Clyde Edwards-Helaire | RB | KC |
| SF10 | 8 | 2 | 86 | Mitch Trubisky | QB | PIT |
| Prometheus | 8 | 3 | 87 | AJ Dillon | RB | GB |
| LetsGo!!! | 8 | 4 | 88 | Adam Thielen | WR | MIN |
| Sports Doctor SFBB21* | 8 | 5 | 89 | Deshaun Watson | QB | CLE |
| OTLY | 8 | 6 | 90 | Zach Ertz | TE | ARI |
| Team XXX | 8 | 7 | 91 | Elijah Mitchell | RB | SF |
| Fly | 8 | 8 | 92 | Antonio Gibson | RB | WAS |
| Lucky 3s | 8 | 9 | 93 | Gabe Davis | WR | BUF |
| Hammers 89 | 8 | 10 | 94 | Ken Walker | RB | SEA |
| StitchCurry | 8 | 11 | 95 | DK Metcalf | WR | SEA |
| russnuss | 8 | 12 | 96 | Jacoby Brissett | QB | CLE |
| russnuss | 9 | 1 | 97 | Kareem Hunt | RB | CLE |
| StitchCurry | 9 | 2 | 98 | Darnell Mooney | WR | CHI |
| Hammers 89 | 9 | 3 | 99 | Rashod Bateman | WR | BAL |
| Lucky 3s | 9 | 4 | 100 | Jerry Jeudy | WR | DEN |
| Fly | 9 | 5 | 101 | Chase Edmonds | RB | MIA |
| Team XXX | 9 | 6 | 102 | Kenny Pickett | QB | PIT |
| OTLY | 9 | 7 | 103 | Elijah Moore | WR | NYJ |
| Sports Doctor SFBB21* | 9 | 8 | 104 | Michael Thomas | WR | NO |
| LetsGo!!! | 9 | 9 | 105 | Geno Smith | QB | SEA |
| Prometheus | 9 | 10 | 106 | Miles Sanders | RB | PHI |
| SF10 | 9 | 11 | 107 | Drake London | WR | ATL |
| WHAT A WASTE | 9 | 12 | 108 | Tony Pollard | RB | DAL |
| WHAT A WASTE | 10 | 1 | 109 | Irv Smith | TE | MIN |
| SF10 | 10 | 2 | 110 | Kadarius Toney | WR | NYG |
| Prometheus | 10 | 3 | 111 | DeVonta Smith | WR | PHI |
| LetsGo!!! | 10 | 4 | 112 | Tyler Lockett | WR | SEA |
| Sports Doctor SFBB21* | 10 | 5 | 113 | Rashaad Penny | RB | SEA |
| OTLY | 10 | 6 | 114 | Rhamondre Stevenson | RB | NE |
| Team XXX | 10 | 7 | 115 | Devin Singletary | RB | BUF |
| Fly | 10 | 8 | 116 | Hunter Renfrow | WR | LV |
| Lucky 3s | 10 | 9 | 117 | Allen Lazard | WR | GB |
| Hammers 89 | 10 | 10 | 118 | Skyy Moore | WR | KC |
| StitchCurry | 10 | 11 | 119 | Amari Cooper | WR | CLE |
| russnuss | 10 | 12 | 120 | DeAndre Hopkins | WR | ARI |
| russnuss | 11 | 1 | 121 | James Cook | RB | BUF |
| StitchCurry | 11 | 2 | 122 | Dawson Knox | TE | BUF |
| Hammers 89 | 11 | 3 | 123 | Dameon Pierce | RB | HOU |
| Lucky 3s | 11 | 4 | 124 | Damien Harris | RB | NE |
| Fly | 11 | 5 | 125 | Cordarrelle Patterson | RB | ATL |
| Team XXX | 11 | 6 | 126 | Tyler Boyd | WR | CIN |
| OTLY | 11 | 7 | 127 | Melvin Gordon | RB | DEN |
| Sports Doctor SFBB21* | 11 | 8 | 128 | Brandon Aiyuk | WR | SF |
| LetsGo!!! | 11 | 9 | 129 | Christian Kirk | WR | JAC |
| Prometheus | 11 | 10 | 130 | Cole Kmet | TE | CHI |
| SF10 | 11 | 11 | 131 | Chris Olave | WR | NO |
| WHAT A WASTE | 11 | 12 | 132 | Ronald Jones | RB | KC |
| WHAT A WASTE | 12 | 1 | 133 | Robert Woods | WR | TEN |
| SF10 | 12 | 2 | 134 | Treylon Burks | WR | TEN |
| Prometheus | 12 | 3 | 135 | Albert Okwuegbunam | TE | DEN |
| LetsGo!!! | 12 | 4 | 136 | Noah Fant | TE | SEA |
| Sports Doctor SFBB21* | 12 | 5 | 137 | Isaiah Spiller | RB | LAC |
| OTLY | 12 | 6 | 138 | Mike Gesicki | TE | MIA |
| Team XXX | 12 | 7 | 139 | Rachaad White | RB | TB |
| Fly | 12 | 8 | 140 | Pat Freiermuth | TE | PIT |
| Lucky 3s | 12 | 9 | 141 | Hunter Henry | TE | NE |
| Hammers 89 | 12 | 10 | 142 | Gerald Everett | TE | LAC |
| StitchCurry | 12 | 11 | 143 | Tyler Higbee | TE | LAR |
| russnuss | 12 | 12 | 144 | Marquez Valdes-Scantling | WR | KC |
| russnuss | 13 | 1 | 145 | Rondale Moore | WR | ARI |
| StitchCurry | 13 | 2 | 146 | Tyrion Davis-Price | RB | SF |
| Hammers 89 | 13 | 3 | 147 | DeVante Parker | WR | NE |
| Lucky 3s | 13 | 4 | 148 | Nyheim Hines | RB | IND |
| Fly | 13 | 5 | 149 | Russell Gage | WR | TB |
| Team XXX | 13 | 6 | 150 | Alexander Mattison | RB | MIN |
| OTLY | 13 | 7 | 151 | Tyler Allgeier | RB | ATL |
| Sports Doctor SFBB21* | 13 | 8 | 152 | Chase Claypool | WR | PIT |
| LetsGo!!! | 13 | 9 | 153 | Jamison Crowder | WR | BUF |
| Prometheus | 13 | 10 | 154 | Michael Carter | RB | NYJ |
| SF10 | 13 | 11 | 155 | Joshua Palmer | WR | LAC |
| WHAT A WASTE | 13 | 12 | 156 | Mo Alie-Cox | TE | IND |
| WHAT A WASTE | 14 | 1 | 157 | Robert Tonyan | TE | GB |
| SF10 | 14 | 2 | 158 | Kenneth Gainwell | RB | PHI |
| Prometheus | 14 | 3 | 159 | Mecole Hardman | WR | KC |
| LetsGo!!! | 14 | 4 | 160 | Khalil Herbert | RB | CHI |
| Sports Doctor SFBB21* | 14 | 5 | 161 | Darrell Henderson | RB | LAR |
| OTLY | 14 | 6 | 162 | Jimmy Garoppolo | QB | SF |
| Team XXX | 14 | 7 | 163 | Romeo Doubs | WR | GB |
| Fly | 14 | 8 | 164 | Garrett Wilson | WR | NYJ |
| Lucky 3s | 14 | 9 | 165 | James Robinson | RB | JAC |
| Hammers 89 | 14 | 10 | 166 | Isiah Pacheco | RB | KC |
| StitchCurry | 14 | 11 | 167 | Sam Darnold | QB | CAR |
| russnuss | 14 | 12 | 168 | David Njoku | TE | CLE |
| russnuss | 15 | 1 | 169 | Michael Gallup | WR | DAL |
| StitchCurry | 15 | 2 | 170 | Evan Engram | TE | JAC |
| Hammers 89 | 15 | 3 | 171 | Jalen Tolbert | WR | DAL |
| Lucky 3s | 15 | 4 | 172 | Austin Hooper | TE | TEN |
| Fly | 15 | 5 | 173 | Kenny Golladay | WR | NYG |
| Team XXX | 15 | 6 | 174 | K.J. Osborn | WR | MIN |
| OTLY | 15 | 7 | 175 | J.D. McKissic | RB | WAS |
| Sports Doctor SFBB21* | 15 | 8 | 176 | Jahan Dotson | WR | WAS |
| LetsGo!!! | 15 | 9 | 177 | Drew Lock | QB | SEA |
| Prometheus | 15 | 10 | 178 | Jamaal Williams | RB | DET |
| SF10 | 15 | 11 | 179 | Zamir White | RB | LV |
| WHAT A WASTE | 15 | 12 | 180 | Jakobi Meyers | WR | NE |
| WHAT A WASTE | 16 | 1 | 181 | Robbie Anderson | WR | CAR |
| SF10 | 16 | 2 | 182 | Julio Jones | WR | TB |
| Prometheus | 16 | 3 | 183 | Jameson Williams | WR | DET |
| LetsGo!!! | 16 | 4 | 184 | Sammy Watkins | WR | GB |
| Sports Doctor SFBB21* | 16 | 5 | 185 | Raheem Mostert | RB | MIA |
| OTLY | 16 | 6 | 186 | Desmond Ridder | QB | ATL |
| Team XXX | 16 | 7 | 187 | Van Jefferson | WR | LAR |
| Fly | 16 | 8 | 188 | Christian Watson | WR | GB |
| Lucky 3s | 16 | 9 | 189 | Marlon Mack | RB | HOU |
| Hammers 89 | 16 | 10 | 190 | Logan Thomas | TE | WAS |
| StitchCurry | 16 | 11 | 191 | Jarvis Landry | WR | NO |
| russnuss | 16 | 12 | 192 | DJ Chark | WR | DET |
| russnuss | 17 | 1 | 193 | Gus Edwards | RB | BAL |
| StitchCurry | 17 | 2 | 194 | Brian Robinson | RB | WAS |
| Hammers 89 | 17 | 3 | 195 | Isaiah McKenzie | WR | BUF |
| Lucky 3s | 17 | 4 | 196 | Taysom Hill | TE | NO |
| Fly | 17 | 5 | 197 | Hayden Hurst | TE | CIN |
| Team XXX | 17 | 6 | 198 | Cameron Brate | TE | TB |
| OTLY | 17 | 7 | 199 | Darrel Williams | RB | ARI |
| Sports Doctor SFBB21* | 17 | 8 | 200 | Kenyan Drake | RB | LV |
| LetsGo!!! | 17 | 9 | 201 | C.J. Uzomah | TE | NYJ |
| Prometheus | 17 | 10 | 202 | Nico Collins | WR | HOU |
| SF10 | 17 | 11 | 203 | KJ Hamler | WR | DEN |
| WHAT A WASTE | 17 | 12 | 204 | Marvin Jones | WR | JAC |
| WHAT A WASTE | 18 | 1 | 205 | Byron Pringle | WR | CHI |
| SF10 | 18 | 2 | 206 | Trey McBride | TE | ARI |
| Prometheus | 18 | 3 | 207 | Corey Davis | WR | NYJ |
| LetsGo!!! | 18 | 4 | 208 | Will Dissly | TE | SEA |
| Sports Doctor SFBB21* | 18 | 5 | 209 | Jerick McKinnon | RB | KC |
| OTLY | 18 | 6 | 210 | Mark Ingram | RB | NO |
| Team XXX | 18 | 7 | 211 | Chris Evans | RB | CIN |
| Fly | 18 | 8 | 212 | Brevin Jordan | TE | HOU |
| Lucky 3s | 18 | 9 | 213 | Wan'Dale Robinson | WR | NYG |
| Hammers 89 | 18 | 10 | 214 | Tyler Badie | RB | BAL |
| StitchCurry | 18 | 11 | 215 | Tim Patrick | WR | DEN |
| russnuss | 18 | 12 | 216 | George Pickens | WR | PIT |
| russnuss | 19 | 1 | 217 | D'Ernest Johnson | RB | CLE |
| StitchCurry | 19 | 2 | 218 | D'Onta Foreman | RB | CAR |
| Hammers 89 | 19 | 3 | 219 | Gardner Minshew | QB | PHI |
| Lucky 3s | 19 | 4 | 220 | Alec Pierce | WR | IND |
| Fly | 19 | 5 | 221 | Parris Campbell | WR | IND |
| Team XXX | 19 | 6 | 222 | Nick Westbrook-Ikhine | WR | TEN |
| OTLY | 19 | 7 | 223 | Cade Otton | TE | TB |
| Sports Doctor SFBB21* | 19 | 8 | 224 | Eno Benjamin | RB | ARI |
| LetsGo!!! | 19 | 9 | 225 | Sony Michel | RB | MIA |
| Prometheus | 19 | 10 | 226 | Donovan Peoples-Jones | WR | CLE |
| SF10 | 19 | 11 | 227 | Kendrick Bourne | WR | NE |
| WHAT A WASTE | 19 | 12 | 228 | Curtis Samuel | WR | WAS |
| WHAT A WASTE | 20 | 1 | 229 | Odell Beckham | WR | FA |
| SF10 | 20 | 2 | 230 | Malik Willis | QB | TEN |
| Prometheus | 20 | 3 | 231 | Terrace Marshall | WR | CAR |
| LetsGo!!! | 20 | 4 | 232 | Matt Breida | RB | NYG |
| Sports Doctor SFBB21* | 20 | 5 | 233 | James Proche | WR | BAL |
| OTLY | 20 | 6 | 234 | Tyler Huntley | QB | BAL |
| Team XXX | 20 | 7 | 235 | David Bell | WR | CLE |
| Fly | 20 | 8 | 236 | Hassan Haskins | RB | TEN |
| Lucky 3s | 20 | 9 | 237 | A.J. Green | WR | ARI |
| Hammers 89 | 20 | 10 | 238 | Tyquan Thornton | WR | NE |
| StitchCurry | 20 | 11 | 239 | Jeff Wilson | RB | SF |
| russnuss | 20 | 12 | 240 | Daniel Bellinger | TE | NYG |
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